The effect of p22-PHOX (CYBA) polymorphisms on premature coronary artery disease (≤ 40 years of age)

Georg Goliasch; Franz Wiesbauer; Andreas Grafl; Elisabeth Ponweiser; Hermann Blessberger; Ioannis Tentzeris; Johann Wojta; Martin Schillinger; Kurt Huber; Gerald Maurer; Christine Mannhalter; Raute Sunder-Plaßmann

doi:10.1160/TH10-08-0529

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2011; 105(03): 529-534
DOI: 10.1160/TH10-08-0529

Cardiovascular Biology and Cell Signalling

Schattauer GmbH

The effect of p22-PHOX (CYBA) polymorphisms on premature coronary artery disease (≤ 40 years of age)

Georg Goliasch

¹Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria

,

Franz Wiesbauer

¹Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria

,

Andreas Grafl

²Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

,

Elisabeth Ponweiser

²Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

,

Hermann Blessberger

¹Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria

,

Ioannis Tentzeris

³3^rd Department of Internal medicine, Cardiology and Emergency Medicine, Wilhelminen Hospital Vienna, Austria

,

Johann Wojta

¹Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria

,

Martin Schillinger

¹Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria

,

Kurt Huber

³3^rd Department of Internal medicine, Cardiology and Emergency Medicine, Wilhelminen Hospital Vienna, Austria

,

Gerald Maurer

¹Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria

,

Christine Mannhalter

²Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

,

Raute Sunder-Plaßmann

¹Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria

› Author Affiliations

Abstract

Summary

Acute myocardial infarction at a young age is associated with high morbidity and long-term mortality. The NADPH oxidase system as a main source of reactive oxygen species in vascular cells has been implicated in development and progression of coronary artery disease (CAD). In our study, we investigated the effect of polymorphisms in the p22-PHOX (CYBA) gene on CAD in young patients (≤ 40 years). We prospectively recruited 302 subjects into our multi-centre case control study, including 102 young myocardial infarction patients (≤ 40 years) from two high-volume cardiac catheterisation hospitals and frequency-matched them on age, gender, and center to 200 hospital controls in an approximate 2:1 ratio per case patient. The homozygote c.-930A>G promoter polymorphism was significantly more prevalent in the controls than in the infarction patients. In the adjusted logistic regression analysis, we detected a protective effect of the c.-930A>G promoter polymorphism against premature myocardial infarction. Using a logadditive/per-allele model, we detected an unadjusted odds ratio (OR) of 0.63 (95% confidence interval [CI] 0.45–0.9, p-value 0.011). In the adjusted model the association was more pronounced with an OR of 0.5 (95% CI 0.3–0.81, p-value 0.005). The C242T polymorphism and the 640A>G polymorphism did not differ significantly between the study groups. Furthermore we could not detect a significant effect for these polymorphisms in the logistic regression analysis. The present study suggests a protective association between the c.-930A>G promoter polymorphism in the p22-PHOX (CYBA) gene and the development of myocardial infarction in young individuals (≤ 40 years).

Keywords

Premature coronary artery disease - myocardial infarction - p22-PHOX (CYBA) - ROS - epidemiology

Full Text

References

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