Studies on Fletcher trait and Fitzgerald trait

Hidehiko Saito

doi:10.1160/TH10-01-0058

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2010; 104(05): 867-874
DOI: 10.1160/TH10-01-0058

Theme Issue Article

Schattauer GmbH

Studies on Fletcher trait and Fitzgerald trait

A rare chance to disclose body’s defense reactions against injury

Authors

Hidehiko Saito

¹Nagoya Central Hospital, Nagoya, Japan

Abstract

Summary

The way by which contact of blood with foreign surface accelerates clotting has been elucidated from the discovery of four rare disorders of blood coagulation; Hageman trait, plasma thromboplastin antecedent (PTA) deficiency, Fletcher trait, and Fitzgerald trait. Interestingly, it was unexpectedly found that Fletcher factor is plasma prekallikrein and Fitzgerald factor is high-molecular-weight kininogen; components of the kinin-generating system, thus disclosing intimate relationships among clotting, fibrinolysis and kinin generation which may be viewed as body’s defense reactions against injury. This review mainly reflects our research on Fletcher trait and Fitzgerald trait during the 1970s in Cleveland.

Keywords

Contact factor - kinin system - fibrinolysis - Fletcher trait - Fitzgerald trait

Full Text

References

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