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Thromb Haemost 2008; 99(06): 1035-1039
DOI: 10.1160/TH08-02-0107
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Deep vein thrombosis in patients with chronic kidney disease

H. Leon Daneschvar
1   Cardiovascular Medicine Division, Department of Medicine, Brigham and Women’s Hospital; Harvard Medical School, Boston, Massachussetts, USA
,
Ali Seddighzadeh
1   Cardiovascular Medicine Division, Department of Medicine, Brigham and Women’s Hospital; Harvard Medical School, Boston, Massachussetts, USA
,
Gregory Piazza
2   Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachussetts, USA
,
Samuel Z. Goldhaber
1   Cardiovascular Medicine Division, Department of Medicine, Brigham and Women’s Hospital; Harvard Medical School, Boston, Massachussetts, USA
› Author AffiliationsFinancial support: This study was funded, in part, by a research grant from Sanofi Aventis.
Further Information

Publication History

Received 24 February 2008

Accepted after major revision 09 April 2008

Publication Date:
27 November 2017 (online)

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Summary

Deep vein thrombosis (DVT) is a poorly understood complication of chronic kidney disease (CKD). The objective of our analysis was to profile DVT patients with and without CKD. We defined CKD as patients requiring dialysis or patients having nephrotic syndrome.We compared 268 patients with CKD (184 patients with dialysis-dependent renal disease and 84 with nephrotic syndrome) to 4,307 patients with preserved renal function from a prospective United States multicenter deep venous thrombosis (DVT) registry. Compared with non-CKD patients, CKD patients with DVT were younger (median age 62 vs. 69 years, p<0.0001), more often African- American (p<0.0001), and more often Hispanic (p=0.0003). CKD patients underwent surgery more frequently in the three months prior to developing DVT (48.9% vs. 39.0%, p=0.001) and more often had concomitant congestive heart failure (20.9% vs. 14.6%, p=0.005). CKD patients suffered upper extremity DVT more frequently (30.0% vs. 10.8%, p<0.0001). Patients with CKD presented less often with typical DVT symptoms of extremity discomfort (42.9% vs. 52.4%, p=0.003) and difficulty ambulating (5.4% vs. 10.1%, p=0.01). Prophylaxis rates prior to DVT were similarly low in CKD and non-CKD patients (44.2% vs. 38.0%, p=0.06). Future studies of DVT in CKD patients should explore novel strategies for improving prophylaxis utilization and the detection of DVT in this special population.

Keywords

Chronic kidney disease - deep venous thrombosis - pulmonary embolism - prevention - renal failure - venous thromboembolism
 

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