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Thromb Haemost 2008; 99(03): 457-460
DOI: 10.1160/TH07-11-0692
Editorial Focus
Schattauer GmbH

A renaissance for the contact system in blood coagulation?

Yuval Blat
1   Department of Chemical Enzymology
,
Dietmar Seiffert
2   Department of Thrombosis Biology, Bristol-Myers Squibb Company, Pennington, New Jersey, USA
› Author Affiliations
Further Information

Publication History

Received: 20 November 2007

Accepted after major revision: 13 January 2008

Publication Date:
07 December 2017 (online)

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  • References

  • 1 Colman RW. Contact activation pathway: Inflammatory, fibrinolytic, anticoagulant, antiadhesive and antiangiogenic activities. Haemostasis and thrombosis. Lippincott Williams & Wilkins; Philadelphia: 2001: 104-121.
    Search in Google Scholar
  • 2 Joseph K, Kaplan AP. Formation of bradykinin: a major contributor to the innate inflammatory response. Adv Immunol 2005; 86: 159-208.
    PubMedSearch in Google Scholar
  • 3 Shariat-Madar Z, Schmaier AH. The plasma kallikrein/ kinin and renin angiotensin systems in blood pressure regulation in sepsis. J Endotoxin Res 2004; 10: 3-13.
    PubMedSearch in Google Scholar
  • 4 Renne T, Gailani D. Role of Factor XII in haemostasis and thrombosis: clinical implications. Expert Rev Cardiovasc Ther 2007; 5: 733-741.
    CrossrefPubMedSearch in Google Scholar
  • 5 Iwaki T, Castellino FJ. Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thromb Haemost 2006; 95: 1003-1010.
    Thieme ConnectPubMedSearch in Google Scholar
  • 6 Minnema MC, ten Cate H, Hack EC. The role of factor XI in coagulation: A matter of revision. Semin Thromb Haemost 1999; 25: 419-428.
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Walsh PN. Factor XI. Haemostasis and Thrombosis. Lippincott Williams & Wilkins; Philadelphia: 2001: 191-202.
    Search in Google Scholar
  • 8 Gailani D, Broze GJJ. Factor XI activation in a revised model of blood coagulation. Science 1991; 253: 909-912.
    CrossrefPubMedSearch in Google Scholar
  • 9 Naito K, Fujikawa K. Activation of human blood coagulation factor XI independent of factor XII. J Biol Chem 1991; 266: 7353-7358.
    PubMedSearch in Google Scholar
  • 10 Brunnee T, La Porta C, Reddigari SR. et al. Activation of factor XI in plasma is dependent on factor XII. Blood 1993; 81: 580-586.
    PubMedSearch in Google Scholar
  • 11 Scott CF, Colman RW. Fibrinogen blocks the autoactivation and thrombin-mediated activation of thrombin on dextran sulfate. Proc Natl Acad Sci USA 1992; 89: 11189-1193.
    CrossrefPubMedSearch in Google Scholar
  • 12 Bouma BN, Mosiner LO, Meijers JCM. et al. Factor XI dependent and independent activation of thrombin activatable fibrinolysis inhibitor (TAFI) in plasma associated with clot formation. Thromb Haemost 1999; 82: 1703-1708.
    Thieme ConnectPubMedSearch in Google Scholar
  • 13 He R, Xiong S, He X. et al. The role of factor XI In a dilute thromboplastin assay of extrinsic coagulation pathway. Thromb Haemost 2001; 85: 1055-1059.
    Thieme ConnectPubMedSearch in Google Scholar
  • 14 Keularts IMLW, Zivelin A, Seligsohn U. et al. The role of factor XI in thrombin generation induced by low concentrations of tissue factor. Thromb Haemost 2001; 85: 1060-1065.
    Thieme ConnectPubMedSearch in Google Scholar
  • 15 von dem Borne PA, Bajzar L, Meijers JC. et al. Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysis. J Clin Invest 1997; 99: 2323-2327.
    CrossrefPubMedSearch in Google Scholar
  • 16 von dem Borne PAK, Meijers JCM, Bouma BN. Feedback activation of factor XI by thrombin in plasma results in additional formation of thrombin that protects fibrin clots from fibrinolysis. Blood 1995; 86: 3035-3042.
    PubMedSearch in Google Scholar
  • 17 Baglia FA, Walsh PN. Prothrombin is a cofactor for the binding of factor XI to the platelet surface and for platelet-mediated factor-XI activation by thrombin. Biochemistry 1998; 37: 2271-2281.
    CrossrefPubMedSearch in Google Scholar
  • 18 Baglia FA, Walsh PN. Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa. J Biol Chem 2000; 275: 20514-20519.
    CrossrefPubMedSearch in Google Scholar
  • 19 Oliver JA, Monroe DM, Roberts HR. et al. Thrombin activates factor XI on activated platelets in the absence of factor XII. Arterioscler Thromb Vasc Biol 1998; 19: 170-177.
    PubMedSearch in Google Scholar
  • 20 Gailani D, Lasky NM, Broze GJ. Jr. A murine model of factor XI deficiency. Blood Coagul Fibrinolysis 1997; 8: 134-144.
    CrossrefPubMedSearch in Google Scholar
  • 21 Renne T, Pozgajova M, Gruner S. et al. Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med 2005; 202: 271-281.
    CrossrefPubMedSearch in Google Scholar
  • 22 Wang X, Cheng Q, Xu L. et al. Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice. J Thromb Haemost 2005; 3: 695-702.
    CrossrefPubMedSearch in Google Scholar
  • 23 Kleinschnitz C, Stoll G, Bendszus M. et al. Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with haemostasis. J Exp Med 2006; 203: 513-518.
    CrossrefPubMedSearch in Google Scholar
  • 24 Colman RW. Are haemostasis and thrombosis two sides of the same coin?. J Exp Med 2006; 203: 493-495.
    CrossrefPubMedSearch in Google Scholar
  • 25 Pedicord DL, Seiffert D, Blat Y. Feedback activation of factor XI by thrombin does not occur in plasma. Proc Natl Acad Sci USA 2007; 104: 12855-12860.
    CrossrefPubMedSearch in Google Scholar
  • 26 Baglia FA, Walsh PN. Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa. . J Biol Chem 2000; 275: 20514-20519.
    CrossrefPubMedSearch in Google Scholar
  • 27 Baglia FA, Walsh PN. Prothrombin is a cofactor for the binding of factor XI to the platelet surface and for platelet-mediated factor-XI activation by thrombin. Biochemistry 2007; 46: 12886-12887.
    CrossrefPubMedSearch in Google Scholar
  • 28 Kannemeier C, Shibamiya A, Nakazawa F. et al. Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci USA 2007; 104: 6388-6393.
    CrossrefPubMedSearch in Google Scholar
  • 29 Smith SA, Mutch NJ, Baskar D. et al. Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci USA 2006; 103: 903-908.
    CrossrefPubMedSearch in Google Scholar
  • 30 Ruiz FA, Lea CR, Oldfield E. et al. Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem 2004; 279: 44250-44257.
    CrossrefPubMedSearch in Google Scholar
  • 31 Brush PJ, Anderson PH, Gunning RF. Identification of factor XI deficiency in Holstein-Friesian cattle in Britain. Vet Rec 1987; 121: 14-17.
    CrossrefPubMedSearch in Google Scholar
  • 32 Smith D, Gilbert M, Owen WG. Tissue plasminogen activator release in vivo in response to vasoactive agents. Blood 1985; 66: 835-839.
    PubMedSearch in Google Scholar
  • 33 Hasan AA, Amenta S, Schmaier AH. Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, are selective inhibitors of alpha-thrombin-induced platelet activation. Circulation 1996; 94: 517-528.
    CrossrefPubMedSearch in Google Scholar