Successful outcome in a pregnant woman with homozygous antithrombin deficiency

Thromb Haemost 2007; 98(06): 1377-1378
DOI: 10.1160/TH07-04-0282

Case Report

Schattauer GmbH

Guelay Alguel

¹Division of Hematology and Hemostaseology, Department of Medicine I

,

Kristin Jochmans

²Laboratory of Hematology, Academic Hospital of the Free University of Brussels, Brussels, Belgium

,

Ralph Simanek

¹Division of Hematology and Hemostaseology, Department of Medicine I

,

Cihan Ay

¹Division of Hematology and Hemostaseology, Department of Medicine I

,

Peter Quehenberger

³Clinical Institute of Medical and Chemical Laboratory Diagnostics

,

Martin Langer

⁴Department of Obstetrics and Gynecology, all Medical University Vienna, Vienna, Austria

,

Ingrid Pabinger

¹Division of Hematology and Hemostaseology, Department of Medicine I

References
1 Thaler E, Lechner K. Antithrombin III deficiency and thromboembolism. Clin Haematol 1981; 10: 369-390.
2 Kuhle S, Lane DA, Jochmanns K. et al. Homozygous antithrombin deficiency type II (99 Leu to Phe mutation) and childhood thromboembolism. Thromb Haemost 2001; 86: 1007-1011.
3 Preston FE, Rosendaal FR, Walker ID. et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348: 913-916.
4 Pabinger I, Vormittag R. Thrombophilia and pregnancy outcomes. J Thromb Haemost 2005; 3: 1603-1610.
5 Finazzi G, Caccia R, Barbui T. Different prevalence of thromboembolism in the subtypes of congenital antithrombin III deficiency: review of 404 cases. Thromb Haemost 1987; 58: 1094.
6 Olds RJ, Lane DA, Boisclair M. et al. Antithrombin Budapest 3. An antithrombin variant with reduced heparin affinity resulting from the substitution L99F. FEBS Lett 1992; 300: 241-246.
7 Bauters A, Zawadzki C, Bura A. et al. Homozygous variant of antithrombin with lack of affinity for heparin: management of severe thrombotic complications associated with intrauterine fetal demise. Blood Coagul Fibrinolysis 1996; 7: 705-710.
8 Hadlock FP, Harrist RB, Martinez-Poyer J. In utero analysis of fetal growth: a sonographic weight standard. Radiology 1991; 181: 129-133.