Age- and gender-related differences of plasma prothrombin activity levels

• References

• 1 White RH. The epidemiology of venous thromboembolism. Circulation 2003; 107: I4-8.
• 2 Feinbloom D, Bauer KA. Assessment of hemostatic risk factors in predicting arterial thrombotic events. Arterioscler Thromb Vasc Biol 2005; 25: 2043-2053.
• 3 Couturaud F, Kearon C, Leroyer C. et al Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. Thromb Haemost 2006; 96: 744-749.
• 4 Mannami T, Baba S, Ogata J. Strong and significant relationships between aggregation of major coronary risk factors and the acceleration of carotid atherosclerosis in the general population of a Japanese city: the Suita Study. Arch Intern Med 2000; 160: 2297-2303.
• 5 Tofler GH, Massaro J, Levy D. et al Relation of the prothrombotic state to increasing age (from the Framingham Offspring Study). Am J Cardiol 2005; 96: 1280-1283.
• 6 Butenas S, van't Veer C, Mann KG. "Normal" thrombin generation. Blood 1999; 94: 2169-2178.
• 7 Poort SR, Rosendaal FR, Reitsma PH. et al A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-3703.
• 8 Ye Z, Liu EH, Higgins JP. et al Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet 2006; 367: 651-658.
• 9 Miyata T, Kawasaki T, Fujimura H. et al The prothrombin gene G20210A mutation is not found among Japanese patients with deep vein thrombosis and healthy individuals. Blood Coagul Fibrinolysis 1998; 9: 451-452.
• 10 Yamada D, Morita T. CA-1 method, a novel assay for quantification of normal prothrombin using a Ca2+-dependent prothrombin activator, carinactivase- 1. Thromb Res 1999; 94: 221-226.
• 11 Bauer KA, Weiss LM, Sparrow D. et al Aging-associated changes in induces of thrombin generation and protein C activation in humans. J Clin Invest 1987; 80: 1527-1534.
• 12 Mari D, Mannucci PM, Coppola R. et al Hypercoagulability in centenarians: the paradox of successful aging. Blood 1995; 85: 3144-3149.
• 13 Miyata T, Kimura R, Kokubo Y. et al Genetic risk factors for deep vein thrombosis among Japanese: Importance of protein S K196E mutation. Int J Hematol 2006; 83: 217-223.
• 14 White RH, Dager WE, Zhou H. et al Racial and gender differences in the incidence of recurrent venous thromboembolism. Thromb Haemost 2006; 96: 267-273.
• 15 Sakata T, Kario K, Matsuo T. et al Suppression of plasma activated factor VII levels by warfarin therapy. Arterioscler Thromb Vasc Biol 1995; 15: 241-246.
• 16 White RH, McBurnie MA, Manolio T. et al Oral anticoagulation in patients with atrial fibrillation: adherence with guidelines in an elderly cohort. Am J Med 1999; 106: 165-171.