Extra- and intracellular innate immune recognition in endothelial cells

Bastian Opitz; Stefan Hippenstiel; Julia Eitel; Norbert Suttorp

doi:10.1160/TH06-12-0694

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(02): 319-326
DOI: 10.1160/TH06-12-0694

Review Article

Schattauer GmbH

Extra- and intracellular innate immune recognition in endothelial cells

Authors

Bastian Opitz

¹Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Stefan Hippenstiel

¹Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Julia Eitel

¹Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Norbert Suttorp

¹Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany

Abstract

Summary

The innate immune system represents the principal sensor of infections in multicellular organisms and might also mediate responses to some endogenous molecules. In this context, endothelial cells are among the first cells coming into contact with microbial or endogenous (danger-associated) molecules or whole pathogens entering the bloodstream. Since many bacteria and viruses invade the endothelium, endothelial cells are equipped with both extracellular and cytosolic surveillance systems capable of sensing microbial components, and endogenous danger-associated molecules. The receptor molecules, called pattern recognition receptors (PRRs), are classified as transmembrane or cytosolic molecules. While the transmembrane PRRs recognize extracellular and membrane-enclosed foreign organisms, the cytosolic PRRs appear to sense intracellular infections. Here we focus on both PRR classes in general, and outline the current knowledge of extra- and intracellular pattern recognition in endothelial cells and its potential role in vascular diseases and sepsis.

Keywords

Toll-like receptors - Nod-like receptors - CARD-helicases - endothelial cells

Full Text

References

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