Thromb Haemost 2007; 97(02): 317-318
DOI: 10.1160/TH06-10-0608
Case Report
Schattauer GmbH

Severe neutropenia under clopidogrel treatment three weeks after coronary stenting

Andreas Schäfer
1   Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Julius-Maximilians-Universität Würzburg, Würzburg, Germany
,
Martin Eigenthaler
2   Institut für Klinische Biochemie und Pathobiochemie, Universitätsklinikum Würzburg, Julius-Maximilians-Universität Würzburg, Würzburg, Germany
,
Johann Bauersachs
1   Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Julius-Maximilians-Universität Würzburg, Würzburg, Germany
› Author Affiliations
Further Information

Publication History

Received 27 October 2006

Accepted after revision 06 January 2006

Publication Date:
25 November 2017 (online)

 

 
  • References

  • 1 Eisert WG. Dipyridamole. In: Michelson AD. Platelets [52]. 803-816. 2004. San Diego; Academic Press:
  • 2 Schomig A, Neumann FJ, Kastrati A. et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med 1996; 334: 1084-1089.
  • 3 Gawaz M, Neumann FJ, Ott I. et al. Platelet activation and coronary stent implantation. Effect of antithrombotic therapy. Circulation 1996; 94: 279-285.
  • 4 Schäfer A, Eigenthaler M, Bauersachs J. Platelet activation in heart failure. Clin Lab 2004; 50: 559-566.
  • 5 Hass WK, Easton JD, Adams HP. et al. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. N Engl J Med 1989; 321: 501-507.
  • 6 Ertorer ME, Gokcel A, Savas L. et al. Ticlopidineinduced marrow aplasia treated with cyclosporine. Clin Appl Thromb Hemost 2002; 8: 183-185.
  • 7 Sharis PJ, Cannon CP, Loscalzo J. The antiplatelet effects of ticlopidine and clopidogrel. Ann Intern Med 1998; 129: 394-405.
  • 8 Casella G, Ottani F, Pavesi PC. et al. Safety and efficacy evaluation of clopidogrel compared to ticlopidine after stent implantation: an updated meta-analysis. Ital Heart J 2003; 4: 677-684.
  • 9 Almsherqi ZA, McLachlan CS, Sharef SM. Nonbleeding side effects of clopidogrel: Have large multicenter clinical trials underestimated their incidence?. Int J Cardiol. 2006. in press.
  • 10 A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE) CAPRIE Steering Committee. Lancet 1996; 348: 1329-1339.
  • 11 Coukell AJ, Markham A. Clopidogrel. Drugs 1997; 54: 745-750.
  • 12 Bertrand ME, Rupprecht HJ, Urban P. et al. Doubleblind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting : the clopidogrel aspirin stent international cooperative study (CLASSICS). Circulation 2000; 102: 624-629.
  • 13 Ono K, Kurohara K, Yoshihara M. et al. Agranulocytosis caused by ticlopidine and its mechanism. Am J Hematol 1991; 37: 239-242.
  • 14 Taher A, Ammash Z, Dabajah B. et al. Ticlopidineinduced aplastic anemia and quick recovery with G-CSF: case report and literature review. Am J Hematol 2000; 63: 90-93.