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Thromb Haemost 2005; 94(05): 1112-1113
DOI: 10.1160/TH05-05-1112
Letters to the Editor
Schattauer GmbH

Is elevated factor VIII a risk factor for venous thromboembolism in Canada?

Emmanuel J. Favaloro
1   Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, NSW, Australia
› Author Affiliations Ethics approval: Data presented in this report is part of a larger study assessing the relationship between ABO, age and gender and various laboratory haemostasis parameters. Our institution’s Ethics Committee has approved this study and all blood donors provided informed consent.
Further Information

Publication History

Received: 20 May 2005

Accepted after resubmission:

Publication Date:
14 December 2017 (online)

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  • References

  • 1 Wells PS, Lanlois NJ, Webster MA. et al. Elevated factor VIII is a risk factor for venous thromboembolism in Canada – is it necessary to define a new upper reference range for factor VIII. Thromb Haemost 2005; 93: 842-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Tripodi A. Levels of coagulation factors and venous thrombosis. Haematologica 2003; 88: 705-11.
    PubMedGoogle Scholar
  • 3 Owen DJ, Maclean RM, Pellard S, Collins PW. High concentrations of coagulation factor VIII and thrombosis: is the factor VIII-binding domain of von Willebrand factor implicated?. Br J Haematol 2001; 113: 655-7.
    CrossrefPubMedGoogle Scholar
  • 4 Christina L, Benilde C, Michela C. et al. High levels of factor VIII and risk of recurrence of venous thromboembolism. Br J Haematol 2004; 124: 504-10.
    CrossrefPubMedGoogle Scholar
  • 5 Witsenburg CPJ, Rosendaal FR, Middeldorp JM. et al. Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation. Thromb Res 2005; 115: 387-92.
    CrossrefPubMedGoogle Scholar
  • 6 Bronte-Stewart B, Botha MC, Krut LH. ABO blood groups in relation to ischaemic heart disease. BMJ, 1962; 1: 1646-50.
    CrossrefPubMedGoogle Scholar
  • 7 Jick H, Slone D, Westerholm B. et al. Venous thromboembolic disease and ABO blood type. Lancet 1969; 1: 539-42.
    PubMedGoogle Scholar
  • 8 Preston AE, Barr A. The plasma concentration of factor VIII in the normal population. Br J Haematol, 1964; 10: 238-245.
    CrossrefPubMedGoogle Scholar
  • 9 Schleef M, Strobel E, Dick A. et al. Relationship between ABO and secretor genotype with plasma levels of factor VIII and von Willebrand factor in thrombosis patients and control individuals. Br J Haematol 2004; 128: 100-7.
    PubMedGoogle Scholar
  • 10 Tirado I, Mateo J, Soria JM. et al. The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism. Thromb Haemost 2005; 93: 468-74.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Larsen TB, Johnsen SP, Gislum M. et al. ABO blood groups and risk of venous thromboembolism during pregnancy and the puerperium. A population-based, nested case-control study. J Thromb Haemost 2005; 3: 300-4.
    CrossrefPubMedGoogle Scholar
  • 12 Souto JC, Almasy L, Muniz-Diaz E. et al. Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time. Arterioscler Thromb Vasc Biol 2000; 20: 2024-8.
    CrossrefPubMedGoogle Scholar
  • 13 O’Donnell J, Laffan MA. The relationship between ABO histo-blood group, factor VIII and von Willebrand factor. Transfus Med 2001; 11: 343-51.
    CrossrefPubMedGoogle Scholar
  • 14 O’Donnell J, Boulton FE, Manning RA. et al. Genotype at the secretor blood group locus is a determinant of plasma von Willebrand factor level. Br J Haematol 2002; 116: 350-6.
    CrossrefPubMedGoogle Scholar
  • 15 De Visser MC, Sandkuijl LA, Lensen RP. et al. Linkage analysis of factor VIII and von Willebrand factor loci as quantitative trait loci. J Thromb Haemost 2003; 1: 1771-6.
    CrossrefPubMedGoogle Scholar
  • 16 Morange PE, Tregouet DA, Frere C. et al. Biological and genetic factors influencing plasma factor VIII levels in a healthy family population: results from the Stanislas cohort. Br J Haematol 2005; 128: 91-9.
    CrossrefPubMedGoogle Scholar