Thromb Haemost 2005; 94(03): 682-683
DOI: 10.1160/TH05-03-0682
Letters to the Editor
Schattauer GmbH

Transitory reduction of platelet aggregation with the use of etonogestrel implant in healthy women

Carolina S. Vieira
1   Department of Gynaecology and Obstetrics of the University of São Paulo Ribeirão Preto School of Medicine, Ribeirão Preto, Brazil
,
Rui A. Ferriani
1   Department of Gynaecology and Obstetrics of the University of São Paulo Ribeirão Preto School of Medicine, Ribeirão Preto, Brazil
,
Andréa A. Garcia
2   Department of Haemostasis of the University of São Paulo Ribeirão Preto School of Medicine Hospital das Clínicas, Ribeirão Preto, Brazil
,
Mariana K. O. Gomes
1   Department of Gynaecology and Obstetrics of the University of São Paulo Ribeirão Preto School of Medicine, Ribeirão Preto, Brazil
,
George D. Azevedo
3   Federal University of Rio Grande do Norte, Brazil
,
Marcos F. Silva de Sá
1   Department of Gynaecology and Obstetrics of the University of São Paulo Ribeirão Preto School of Medicine, Ribeirão Preto, Brazil
› Author Affiliations
Financial support: This study received financial support from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Foundation for the Support of Research in the State of São Paulo) and from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, National Council for Scientific and Technological Developmen!t).!
Further Information

Publication History

Received: 23 February 2005

Accepted after major revision: 27 June 2005

Publication Date:
07 December 2017 (online)

 

 
  • References

  • 1 World Health Organization.. Venous thromboembolic disease and combined oral contraceptives: results of international multicentre case-control study.. Lancet 1995; 346: 1575-80.
  • 2 Kemmeren JM, Algra A, Grobbee DE. Third generation oral contraceptives and risk of venous thrombosis: meta-analysis.. BMJ 2001; 323: 131-4.
  • 3 Singh K, Viegas OA, Koh SC. et al. Effect of long term use of Norplant® implants on haemostatic function.. Contraception 1992; 45: 203-19.
  • 4 Singh K, Viegas OA, Koh SC. et al. Effect of Norplant ® –2 rods on haemostatic function.. Contraception 1992; 45: 71-81.
  • 5 Saleh AA, Ginsburg KA, Duchon TA. et al. Hormonal contraception and platelet function.. Thromb Res 1995; 78: 363-7.
  • 6 Egberg N, van Beek A, Gunnervik C. et al. Effects on hemostatic system and liver function in relation to Implanon and Norplant. A prospective randomized clinical trial.. Contraception 1998; 58: 93-8.
  • 7 Khetawat G, Faraday N, Nealen ML. et al. Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): testosterone regulates AR expression.. Blood 2000; 95: 2289-96.
  • 8 Jayachandran M, Miller VM. Human platelets contain estrogen receptor alpha, caveolin-1 and estrogen receptor associated proteins.. Platelets 2003; 14: 75-81.
  • 9 Schindler AE, Campagnoli C, Druckmannc R. et al. Classification and pharmacology of progestins.. Maturitas 2003; 46 (Suppl. 01) S7-S16.
  • 10 Johnson M, Ramey E, Ramwell PW. Androgen-mediated sensitivity in platelet aggregation.. Am J Physiol 1977; 232: 381-5.
  • 11 Lindqvist PG, Rosing J, Malmquist A. et al. Etonogestrel implant use is not related to hypercoagulable changes in anticoagulant system.. J Thromb Haemost 2003; 1: 601-2.
  • 12 Rosing J, Tans G, Nicolaes GA. et al. Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second- and third-generation oral contraceptives.. Br J Haematol 1997; 97: 233-8.
  • 13 Kemmeren JM, Algra A, Meijers JC. et al. Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor V Leiden mutation: a randomized trial.. Blood 2004; 103: 927-33.