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Thromb Haemost 2005; 93(03): 411-413
DOI: 10.1160/TH04-11-0715
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Protein Z and protein Z-dependent protease inhibitor

Determinants of levels and risk of venous thrombosis
Ali Al-Shanqeeti
1   Division of Haematology, Washington University, St. Louis, Missouri, USA
,
Astrid van Hylckama Vlieg
2   The Department of Clinical Epidemiology and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
3   Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
,
Erik Berntorp
4   The Department for Coagulation Disorders, Malmo University Hospital, Sweden
,
Frits R. Rosendaal
2   The Department of Clinical Epidemiology and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
3   Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
,
George J. Broze Jr.
1   Division of Haematology, Washington University, St. Louis, Missouri, USA
› Author AffiliationsFinancial support: This work was supported in part by grants from the National Institutes of Health (HL60782) and the Netherlands Heart Foundation (89.063).
Further Information

Publication History

Received 04 November 2004

Accepted after revision 28 February 2004

Publication Date:
14 December 2017 (online)

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Summary

To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.

Keywords

Coagulation inhibitors - clinical / epidemiological studies - thrombophilia
 

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