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Thromb Haemost 2005; 93(05): 867-871
DOI: 10.1160/TH04-08-0519
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage

Results of a multicentre case-control study
Manuela Krause
1   Department of Internal Medicine, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany
,
Barbara Sonntag
2   Departments of Obstetrics and Gynecology, University of Münster, Germany
,
Robert Klamroth
3   Department of Internal Medicine, Vivantes Hospital Berlin Friedrichshain, Germany
,
Achim Heinecke
4   Institute of Medical Informatics and Biomathematics, University of Münster, Germany
,
Carola Scholz
5   Pediatric Hematology and Oncology, University of Münster, Germany
,
Claus Langer
6   Institute of Clinical Chemistry and Institute of Arteriosclerosis Research, University of Münster, Germany
,
Inge Scharrer
1   Department of Internal Medicine, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany
,
Robert R. Greb
2   Departments of Obstetrics and Gynecology, University of Münster, Germany
,
Arnold von Eckardstein
7   Institute of Clinical Chemistry, University of Zürich, Switzerland
,
Ulrike Nowak-Göttl
5   Pediatric Hematology and Oncology, University of Münster, Germany
› Author AffiliationsThe study was supported by the Forschungsforum Blutgerinnung e. V.
Further Information

Publication History

Received 19 August 2004

Accepted after revision 24 January 2005

Publication Date:
11 December 2017 (online)

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Summary

From 1998 to 2003, 133 Caucasian women aged 17–40 years (median 29 years) suffering from unexplained recurrent miscarriage (uRM) were consecutively enrolled. In patients and 133 age-matched healthy controls prothrombotic risk factors (factor V (FV) G1691A, factor II (FII) G20210A, MTHFR T677T, 4G/5G plasminogen activator inhibitor (PAI)-1, lipoprotein (Lp) (a), protein C (PC), protein S (PS), antithrombin (AT), antiphospholipid/anticardiolipin (APA/ACA) antibodies) as well as associated environmental conditions (smoking and obesity) were investigated. 70 (52.6%) of the patients had at least one prothrombotic risk factor compared with 26 control women (19.5%; p<0.0001). Body mass index (BMI; p=0.78) and smoking habits (p=0.44) did not differ significantly between the groups investigated. Upon univariate analysis the heterozygous FV mutation, Lp(a) > 30 mg/dL, increased APA/ACA and BMI > 25 kg/m2 in combination with a prothrombotic risk factor were found to be significantly associated with uRM. In multivariate analysis, increased Lp(a) (odds ratio (OR): 4.7/95% confidence interval (CI): 2.0–10.7), the FV mutation (OR:3.8/CI:1.4–10.7), and increased APA/ACA (OR: 4.5/CI: 1.1–17.7) had independent associations with uRM.

Keywords

Lipoprotein (a) - recurrent miscarriage

* Each author contributed equally.


 

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