Abstract
A new isoflavone, neocorylin (1) was isolated from the seeds extract of Psoralea corylifolia L. (Fabaceae), together with eight known constituents (2 – 9), i. e., bakuchiol (2), psoralen (3), bavachromene (4), isobavachromene (5), bavachalcone (6), isobavachalcone (7), 7,8-dihydro-8-(4-hydrophenyl)-2,2-dimethyl-2H,6H-[1,2-b:5,4-b′]dipyran-6-one (8), and bavachinin (9). The structure of the new isoflavone 1 was elucidated as 7-hydroxy-3-[2-methyl-2-(4-methylpenten-3-yl)-2H-chromen-6-yl]-4H-chromen-4-one by spectroscopic analyses. Neocorylin (1) as well as related compounds 2, 4 – 6, 8 and 9 exhibited a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
Key words
Psoralea corylifolia L - Fabaceae - BACE-1 - isoflavones - neocorylin
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Dr. Shi Yong Ryu
Korea Reseach Institute of Chemical Technology
Yusung
P.O. Box 107
Daejeon 305–343
Korea
Phone: +82-42-860-7163
Fax: +82-42-861-0307
Email: syryu@krict.re.kr
