Abnormal widening of cortical sulci as seen in posttherapeutic cranial computed tomography
(CCT) of 64 children in complete continuous remission (CCR) of acute lymphoblastic
leucemia (ALL)/non Hodgkin's lymphoma (NHL) was related to patient data and neurological
complications during the application of West Berlin treatment protocol. Age and neurological/neurodevelopmental
findings of the patients at diagnosis of their disease positively and significantly
correlated with CCT abnormalities. Abnormal pre- and intratherapeutic electroencephalographic
(EEG) recordings, the development of a severe polyneuropathy syndrome and/or a considerable
loss of weight during treatment were frequently associated with an abnormal widening
of cortical sulci. Occurrence of transient early encephalopathy syndrome, development
of radiation induced blood brain barrier disturbance and somnolence syndrome were
not correlated with these CCT changes. Possible explanations of these abnormalities
are discussed.
Cranial computed tomography - Childhood leukemia - Age at diagnosis - Neurological
findings - EEG
