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Pneumologie 2008; 62(5): 284-294
DOI: 10.1055/s-2008-1038131
Serie: Tuberkulose
© Georg Thieme Verlag Stuttgart · New York

Klinik und Diagnose der Tuberkulose

Clinical Features and Diagnosis of TuberculosisB.  Kalsdorf1, 2 , A.  Strassburg1 , U.  Greinert1 , J.  Lotz3 , C.  Lange1
  • 1Klinische Infektiologie, Medizinische Klinik, Forschungszentrum Borstel,
  • 2Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Republik Südafrika
  • 3Institut für Radiologie, Medizinische Hochschule Hannover
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Publikationsdatum:
09. April 2008 (online)

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Zusammenfassung

In den vergangenen Jahren hat es bedeutende Fortschritte auf dem Gebiet der Diagnostik der akuten Tuberkulose gegeben. Eine umfassende Tuberkulose-Diagnostik beruht heute auf der Anamneseerhebung und körperlichen Untersuchung und auf den Ergebnissen radiologischer, mikrobiologischer, immunologischer, molekularbiologischer und histologischer Verfahren. Durch Zusammenführung dieser Ergebnisse kann rasch eine aktive Tuberkulose mit hoher Wahrscheinlichkeit klinisch diagnostiziert bzw. ausgeschlossen werden. Dadurch können Therapieentscheidungen frühzeitig fallen. Abhängig von den Ergebnissen der Mycobacterium tuberculosis-Kulturen und Sensitivitätstestungen, müssen diese Entscheidungen u. U. später angepasst werden.

Abstract

Recently, major advances have been accomplished in the diagnosis of active tuberculosis. A comprehensive diagnostic approach for a patient with possible tuberculosis includes a detailed medical history and clinical examination as well as the results of radiological, microbiological, immunological, molecular-biological and histological methods. In concert, these results enable the clinician to rapidly develop a decision with a high probability for the diagnosis or exclusion of active tuberculosis. Therapeutic intervention can thus be made early, even though corrections in these decisions need to be considered depending on the results of Mycobacterium tuberculosis culture and sensitivity testing.

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Priv. Doz. Dr. med. Dipl.-Biol. Christoph Lange

Klinische Infektiologie, Medizinische Klinik, Forschungszentrum Borstel

Parkallee 35

23845 Borstel

eMail: clange@fz-borstel.de