Abstract
An intragastric d -glucose tolerance test was performed, after overnight starvation, in female rats
depleted in long-chain polyunsaturated ω3 fatty acids (ω3D rats) and control rats
of same age and gender. The plasma d -glucose and insulin concentrations, insulinogenic index, and HOMA for insulin resistance
were all higher, after overnight starvation, in ω3D rats than in control animals.
Over the 120-minute period following the intragastric administration of d -glucose, the area under the curve for the same four variables was also higher in
ω3D rats than in control animals. In addition to visceral obesity, liver steatosis,
hypertension, and cardiac hypertrophy, the ω3D rats thus display further features
of the metabolic syndrome, namely glucose intolerance and insulin resistance, despite
hyperinsulinemia.
Key words
metabolic syndrome - HOMA - diabetes - hyperinsulinemia
References
1
Oguzhan B, Sancho V, Acitores A, Villanueva-Peñacarrillo ML, Portois L, Chardigny J-M,
Sener A, Carpentier YA, Malaisse WJ.
Alteration of adipocytes metabolism in ω3 fatty acid-depleted rats.
Horm Metab Res.
2006;
38
789-798
2
Armitage JA, Pearce AD, Sinclair AJ, Vingrys AJ, Weisinger RS, Weisinger HS.
Increased blood pressure late in life may be associated with perinatal n-3 fatty acid
deficiency.
Lipids.
2003;
38
459-464
3
Peltier S, Malaisse WJ, Portois L, Demaison L, Novel-Chate V, Chardigny J-M, Sebedio JL,
Carpentier YA, Leverve XM.
Acute in vivo administration of a fish oil-containing emulsion improves post-ischemic cardiac function
in n-3-depleted rats.
Int J Mol Med.
2006;
18
741-749
4
Oguzhan B, Zhang Y, Louchami K, Courtois P, Portois L, Chardigny J-M, Malaisse WJ,
Carpentier YA, Sener A.
Pancreatic islet function in ω3 fatty acid-depleted rats. Glucose metabolism and nutrient-stimulated
insulin release.
Endocrine.
2006;
29
467-476
5
Prieto PG, Cancelas J, Villanueva-Peñacarrillo ML, Valverde I, Malaisse WJ.
Effects of an olive oil-enriched diet on plasma GLP-1 concentration and intestinal
content, plasma insulin concentration, and glucose tolerance in normal rats.
Endocrine.
2005;
26
107-115
6 Bergmeyer HU, Berndt E. Glucose determination with glucose oxidase and peroxidase. In:
Bergmeyer HU (ed.).
Methods of Enzymatic Analysis . New York: Academic Press 1974: 1205-1215
7
Valverde I, Barreto M, Malaisse WJ.
Stimulation by d -glucose of protein biosynthesis in tumoral insulin-producing cells (RINm5F line).
Endocrinology.
1988;
122
1443-1448
8
Carpentier Y, Agascioglu E, Oguzhan B, Zhang Y, Louchami K, Sener A, Portois L, Malaisse WJ.
Modifications rapides des lipides et du métabolisme glucidique dans le muscle soleus
de rats carencés en acides gras ω3 en réponse à l’injection intraveineuse d’une emulsion
d’huile de poisson et de triglycerides à chaînes moyennes.
Nutr Clin Metab.
2005;
19
((Suppl 1))
P2
, (abstract)
Correspondence
I. ValverdeMD, PhD
Department of Metabolism, Nutrition and Hormones
Fundacíon Jiménez Díaz
Avda. Reyes Católicos 2
28040 Madrid
Spain
Phone: +34/915/50 48 99
Fax: +34/915/44 02 47
Email: ivalverde@fjd.es