Int J Sports Med 2008; 29(7): 559-563
DOI: 10.1055/s-2007-989271
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

MMP-2, Jumping Exercise and Nandrolone in Skeletal Muscle

R. C. Marqueti1 , J. Prestes1 , U. S. Stotzer1 , M. Paschoal1 , R. D. Leite1 , S. E. A. Perez1 , H. S. Selistre de Araujo1
  • 1Ciências Fisiológicas, Universidade Federal de São Carlos, São Carlos, Brazil
Further Information

Publication History

accepted after revision September 13, 2007

Publication Date:
30 November 2007 (online)

Abstract

Matrix metalloproteinases (MMPs) are crucial to the development and maintenance of healthy tissue. The aim of this study was to investigate MMP-2 activity in gastrocnemius, soleus, extensor digitorium longus (EDL) and tibialis anterior (TA) muscles after exercise associated with an anabolic androgenic steroid (AAS). Wistar rats were grouped into: sedentary (S); sedentary with AAS (AAS); trained without (T) and with (AAST) AAS. Exercised groups performed a 7-week water-jumping program. The exercise increased MMP-2 activity in gastrocnemius and soleus, but not in TA and EDL. The AAS treatment decreased MMP-2 activity of EDL, as compared to the S group, with no effect in gastrocnemius and soleus. The association of AAS and training restored the normal MMP activity of EDL. Training increases tissue turnover in primary motor muscles, which in turn respond differently to AAS treatment. This data may be useful for a better understanding of muscular physiology under AAS use.

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Prof. Rita de Cássia Marqueti

Universidade Federal de São Carlos
Ciências Fisiológicas

Washington Luiz, Km 235, Monjolinho

13565905 São Carlos

Brazil

Phone: + 55 16 33 51 83 33

Fax: + 55 16 33 51 83 27

Email: marqueti@gmail.com

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