Novel Epoxyfuranoid Lignans and Antitubercular Constituents from the Leaves of Beilschmiedia tsangii

Abstract

Three new epoxyfuranoid lignans, 4α,5α-epoxybeilschmin A (1), 4α,5α-epoxybeilschmin B (2), and beilschmin D (3), together with nine known compounds have been isolated from the leaves of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (4) and beilschmin B (5) exhibited potent antitubercular activities (MICs = 2.5 and 7.5 μg/mL, respectively) against Mycobacterium tuberculosis 90 - 221 387 in vitro.

Key words

Beilschmiedia tsangii - Lauraceae - epoxyfuranoid lignans - 4α,5α-epoxybeilschmin A - 4α,5α-epoxybeilschmin B - beilschmin D - antitubercular activity

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