Two New Depsipeptides from the Marine Fungus Spicellum roseum

Abstract

Investigation of the secondary metabolites of the marine-derived fungus Spicellum roseum yielded two new cyclohexadepsipeptides, spicellamide A (1) and spicellamide B (2). The structures of 1 and 2 were determined based on extensive evaluations of NMR and MS data. The absolute configuration was deduced after hydrolysis using Marfey's method, chiral chromatography, as well as NOESY and modeling data.

Key words

Spicellum roseum - marine-derived fungi - endophyte - Ectyplasia perox - depsipeptide

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