A 68-year-old woman with a history of Barrett’s esophagus, spinal kyphosis, and Hodgkin’s
lymphoma, who had been treated with mediastinal radiation 25 years before, presented
with a radiation-induced, refractory benign esophageal stricture that had shown only
a limited response to monthly balloon dilations. Endoscopy identified an esophageal
stricture extending from 21 cm to 23 cm. After controlled radial expansion balloon
dilation, a 16 mm × 9 cm, removable, self-expanding plastic stent (Polyflex; Boston
Scientific, Natick, Massachusetts, USA) was deployed across the stricture. Her dysphagia
resolved and the stent was removed 2 months later ([Fig. 1]).
Two weeks later she presented with symptomatic stricture recurrence ([Fig. 2]). An 18 mm × 9 cm Polyflex stent was placed, again with resolution of the dysphagia,
and endoscopy at 6 months and at 8 months revealed the stent to be well positioned,
without any evidence of tissue hyperplasia ([Fig. 1]). At 11 months, she presented with hematemesis and hypotension. Endoscopy identified
massive bleeding at the proximal stent margin, and computed tomography revealed signs
suggestive of esophageal perforation ([Fig. 3]). The patient died after an emergency thoracotomy, which had revealed erosion of
the stent through the esophageal wall into the posterior surface of the aortic arch,
with surrounding inflammation and adhesions.
Fig. 1 Polyflex stent placement. After the first stent was removed, endoscopy revealed a
patent esophageal lumen and mucosal indentation (a). Six weeks after recurrence of the dysphagia, a second Polyflex stent was placed
(b). Endoscopy 6 months and 8 months later revealed no evidence of tissue hyperplasia
at the proximal (c) or distal (d) stent margins.
Fig. 2 Barium esophagram after the first Polyflex stent was removed. There is a stricture
of the proximal esophagus in close proximity to the aortic arch (arrow) and proximal
dilatation of the cervical esophagus. Marked spinal kyphosis is seen in this lateral
view.
Fig. 3 A noncontrast computed tomographic scan of the chest 51 weeks after Polyflex placement,
when the patient presented with massive hematemesis. The stent and a nasogastric tube
can be seen, with a thickened esophageal wall and loss of the fat plane between the
aorta (A) and the esophagus (E). A small area of mediastinal air (arrow) is seen posterior
to the left main-stem bronchus, suggesting esophageal perforation.
Aortoesophageal fistula is a rare, usually fatal, cause of upper gastrointestinal
bleeding, and has not previously been reported following placement of self-expanding
plastic stents. Our patient had recurrence of a post-radiation refractory benign esophageal
stricture after Polyflex stent removal and a program of prolonged placement was then
pursued. Factors which might have increased the risk of serious complications in this
case include: female gender, prior radiation therapy [1], proximal stricture location [2], kyphosis [3], and intestinal metaplasia [4]. While removable self-expanding plastic stents are a promising tool in the treatment
of refractory benign esophageal stricture [5], caution is warranted with prolonged placement. Further data regarding their long-term
safety, comparison with other management strategies, and identification of risk factors
for serious complications are required.
Competing interests: None
Endoscopy_UCTN_Code_CPL_1AH_2AD
