Ernährung und Osteoporose

Zusammenfassung

Die Osteoporose ist eine Erkrankung, deren Ursachen begründet sind in äußeren Einflüssen über die ganze Lebensspanne sowie der genetischen Disposition. Die Ernährung spielt eine wichtige Rolle in der Prävention und Behandlung der Osteoporose. Neben der Kalzium- und Vitamin-D-Aufnahme ist eine Vielzahl von Nahrungsbestandteilen und Ernährungsbedingungen im Zusammenhang von Osteoporose und Ernährung zu berücksichtigen.

Abstract

Osteoporosis is a disease with a genetic background that develops under the influence of environmental factors over the entire life span. Nutrition plays a crucial role in the prevention and treatment of osteoporosis. A number of nutritients and dietary conditions besides calcium and vitamin D intake have to be considered in the context of diet, nutrition and osteoporosis.

Schlüsselwörter

Osteoporose - Ernährung - Diät

Key words

osteoporosis - diet - nutrition

Literatur

• 1 Prentice A. Diet, nutrition and the prevention of osteoporosis.  Public Health Nutr. 2004;  7 227-243
• 2 New S A, Robins S P, Campbell M K. et al . Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?.  Am J Clin Nutr. 2000;  71 142-151
• 3 Hannan M T, Tucker K L, Dawson-Hughes B. et al . Effect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study.  J Bone Miner Res. 2000;  15 2504-2512
• 4 Sellmeyer D E, Stone K L, Sebastian A. et al . A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group.  Am J Clin Nutr. 2001;  73 118-122
• 5 Rizzoli R, Bonjour J P. Determinants of peak bone mass and mechanisms of bone loss.  Osteoporos Int. 1999;  9 S17-23
• 6 Melhus H, Michaelsson K, Kindmark A. et al . Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture.  Ann Intern Med. 1998;  129 770-778
• 7 Lloyd T, Johnson-Rollings N, Eggli D F. et al . Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation.  J Am Coll Nutr. 2000;  19 256-261
• 8 Baumgartner R N, Stauber P M, Koehler K M. et al . Associations of fat and muscle masses with bone mineral in elderly men and women.  Am J Clin Nutr. 1996;  63 365-372
• 9 Goulding A, Taylor R W, Keil D. et al . Lactose malabsorption and rate of bone loss in older women.  Age Ageing. 1999;  28 175-180
• 10 Jackson R D, LaCroix A Z, Gass M. et al . Calcium plus vitamin D supplementation and the risk of fractures.  N Engl J Med. 2006;  354 669-83; Erratum in: N Engl J Med 2006; 354: 1102
• 11 Larsen E R, Mosekilde L, Foldspang A. Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study.  J Bone Miner Res. 2004;  19 370-378
• 12 Food and Nutrition Board, Institute of Medicine .Dietary reference intakes: for Calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, D. C.; National Academy Press 1997: 38-144
• 13 Terris S. Calcium plus Vitamin D and the risk of fractures.  N Engl J Med. 2006;  354 2285-2287
• 14 Finkelstein J S. Calcium plus Vitamin D for Postmenopausal Women - Bone Appetit ?.  N Engl J Med. 2006;  354 750-752; Erratum in: N Engl J Med 2006; 354: 1102
• 15 Kitchin B, Morgan S. Nutritional considerations in osteoporosis.  Curr Opin Rheumatol. 2003;  15 476-480
• 16 Reginster J Y, Zegels B, Lejeune E. et al . Influence of daily regimen calcium and vitamin D supplementation on parathyroid hormone secretion.  Calcif Tissue Int. 2002;  70 78-82
• 17 Jensen C, Holloway L, Block G. et al . Long term effects of nutrient intervention on markers of bone remodeling and calciotropic hormones in late postmenopausal women.  Am J Clin Nutr. 2002;  75 1114-1120
• 18 Cederholm T, Hedström M. Nutritional treatment of bone fracture.  Curr Opin Clin Nutr Metab Care. 2005;  8 377-381
• 19 Nieves J W. Osteoporosis: the role of micronutrients.  Am J Clin Nutr. 2005;  81 1232S-1239S
• 20 Eastell R, Lambert H. Strategies for skeletal health in the elderly.  Proc Nutr Soc. 2002;  61 173-180
• 21 Prophylaxe, Diagnostik und Therapie der Osteoporose bei Frauen ab der Menopause, bei Männern ab dem 60 Lebensjahr. S3 Leitlinie des DVO Dachverband deutschsprachiger wissenschaftlicher Fachgesellschaften zur Osteologie, DVO 2006 www.lutherhaus.de/osteo/leitlinien-dvo
• 22 Prophylaxe, Diagnostik und Therapie der glukokortikoidinduzierten/-assoziierten Osteoporose, vorläufige Leitlinie des DVO, Dachverband deutschsprachiger wissenschaftlicher Fachgesellschaften zur Osteologie. DVO 2006 www.lutherhaus.de/osteo/leitlinien-dvo
• 23 Margolis K L, Ensrud K E, Schreiner P J. et al . Body size and risk for clinical fractures in older women.  Ann Intern Med. 2000;  133 123-127
• 24 Meyer H E, Tverdal A, Falch J A. Body height, body mass index, and fatal hip fractures: 16years’ follow-up of 674.000 Norwegian women and men.  Epidemiology. 1995;  6 299-305
• 25 Chao D, Espeland M A, Farmer D. et al . Effect of voluntary weight loss on bone mineral density in older overweight women.  J Am Geriatr Soc. 2000;  48 753-759
• 26 Ensrud K E, Ewing S K, Stone K L. et al . Study of Osteoporotic Fractures Research Group. Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women.  J Am Geriatr Soc. 2003;  51 1740-1747
• 27 Joakimsen R M, Fonnebo V, Magnus J H. et al . The Tromso Study: body height, body mass index and fractures.  Osteoporos Int. 1998;  8 436-442
• 28 Cadarette S M, McIsaac W J, Hawker G A. et al . The validity of decision rules for selecting women with primary osteoporosis for bone mineral density testing.  Osteoporos Int. 2004;  15 361-6
• 29 De Laet C, Kanis J A, Oden A. et al . Body mass index as a predictor of fracture risk: a meta-analysis.  Osteoporos Int. 2005;  16 1330-1338
• 30 Dawson-Hughes B, Dallal G E, Krall E A. et al . A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women.  N Engl J Med. 1990;  323 878-883
• 31 Komulainen M H, Kroger H, Tuppurainen M T. et al . HRT and Vit D in prevention of non-vertebral fractures in postmenopausal women; a 5 year randomized trial.  Maturitas. 1998;  31 45-54
• 32 Reid I R, Ames R W, Evans M C. et al . Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: A randomized controlled trial.  Am J Med. 1995;  98 331-335
• 33 Cooper L, Clifton-Bligh P B, Nery M L. et al . Vitamin D supplementation and bone mineral density in early postmenopausal women.  Am J Clin Nutr. 2003;  77 1324-1329
• 34 Dawson-Hughes B, Dallal G E, Krall E A. et al . A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women.  N Engl J Med. 1990;  323 878-883
• 35 Dawson-Hughes B, Harris S S, Krall E A. et al . Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.  N Engl J Med. 1997;  337 670-676
• 36 Lips P, Graafmans W C, Ooms M E. et al . Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial.  Ann Intern Med. 1996;  124 400-406
• 37 Trivedi D P, Doll R, Khaw K T. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial.  BMJ. 2003;  326 469
• 38 Chapuy M C, Pamphile R, Paris E. et al . Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study.  Osteoporos Int. 2002;  13 257-264
• 39 Sato Y, Iwamoto J, Kanoko T. et al . Amelioration of osteoporosis and hypovitaminosis D by sunlight exposure in hospitalized, elderly women with Alzheimer’s disease: a randomized controlled trial.  J Bone Miner Res. 2005;  20 1327-1333
• 40 Dawson-Hughes B, Harris S S, Krall E A. et al . Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.  N Engl J Med. 1997;  337 670-676
• 41 Kanis J A, Johnell O, Oden A. et al . Smoking and fracture risk: ameta-analysis.  Osteoporos Int. 2005;  16 155-162
• 42 Meurs J B, Dhonukshe-Rutten R A, Pluijm S M. et al . Homocysteine levels and the risk of osteoporotic fracture.  N Engl J Med. 2004;  350 2033-2041
• 43 Sato van Y, Honda Y, Iwamoto J. et al . Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial.  JAMA. 2005;  293 1082-1088; Erratum in: JAMA 2006; 296: 396
• 44 Kanis J A, Johansson H, Johnell O. et al . Alcohol intake as a risk factor for fracture.  Osteoporos Int. 2005;  16 737-742
• 45 Strohle A, Waldmann A, Wolters M. et al . Vegetarian nutrition: Preventive potential and possible risks Part 1: Plant foods.  Wien Klin Wochenschr. 2006;  118 580-93
• 46 Matkovic V, Goel P K, Badenhop-Stevens N E. et al . Calcium supplementation and bone mineral density in females from childhood to young adulthood: randomized controlled trial.  Am J Clin Nutr. 2005;  81 175-188
• 47 Heaney R P. Functional indices of vitamin D status and ramifications of vitamin D deficiency.  Am J Clin Nutr. 2004;  80 1706S-1709S
• 48 Macdonald H M, New S A, Fraser W D. et al . Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women.  Am J Clin Nutr. 2005;  81 923-933
• 49 Holick M F. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.  Am J Clin Nutr. 2004;  80 1678S-1688S
• 50 Hyun T H, Barrett-Connor E, Milne D B. Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study.  Am J Clin Nutr. 2004;  80 715-721