Haplotypes in the Promoter Region of the ADIPOQ Gene are Associated with Increased Diabetes Risk in a German Caucasian Population

P. E. H. Schwarz; S. Govindarajalu; W. Towers; U. Schwanebeck; S. Fischer; F. Vasseur; S. R. Bornstein; J. Schulze

doi:10.1055/s-2006-947842

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2006; 38(7): 447-451
DOI: 10.1055/s-2006-947842

Original Basic

Haplotypes in the Promoter Region of the ADIPOQ Gene are Associated with Increased Diabetes Risk in a German Caucasian Population

P. E. H. Schwarz¹ , S. Govindarajalu¹ , W. Towers¹ ^, ³ , U. Schwanebeck² , S. Fischer¹ , F. Vasseur⁴ , S. R. Bornstein¹ , J. Schulze¹

¹III° Medical Clinic Department of Endocrinopathies and Metabolic Diseases
²Department of Biometrics, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
³Center for Genome Research, Potchefstroom University for CHE, Pretoria, South Africa
⁴CNRS UMR 8090 and University Hospital of Lille, France

Abstract

Adiponectin, which is encoded by the ADIPOQ gene, has been shown to modulate insulin sensitivity and glucose homeostasis. Plasma adiponectin levels are decreased in type 2 diabetes and obesity. Genetic variations within the ADIPOQ gene are associated with decreased adiponectin hormone levels. To analyze specific single-nucleotide polymorphisms (SNPs) and their association with T2D, 365 German subjects with T2D and 323 control subjects were screened. Three common SNPs - +45T>G in exon 2, and 2 promoter variants SNPs -11391G>A and -11377C>G - were analyzed. We found that the variant allele of SNP -11391G>A was significantly more frequent in the diabetic patient group than in the control group (p=0.003). Carrying the haplotype of SNP -11391A and SNP -11377C was associated with a 1.50-fold (p=0.03) increase in diabetes risk. The combination of the A-C haplotype and the G-C haplotype was associated with significantly elevated diabetes risk (OR=2.82 (95% CI: 1.35-5.91), p=0.006) after correction for BMI and age. Our observations suggest that diploid combinations of haplotype in the adiponectin gene promoter region contribute to the genetic risk of T2D in individuals from a German Caucasian population.

Key words

Adiponectin - ADIPOQ - type 2 diabetes - haplotypes - promoter variants

Full Text

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Correspondence

Dr. med. Peter Egbert Hermann SchwarzIII°

Medical Clinic·Carl Gustav Carus Medical School·Dresden University of Technology

Fetscherstrasse 74·01307 Dresden·Germany

Phone: +49/351/458 27 15

Fax: +49/351/458 87 03

Email: pschwarz@rcs.urz.tu-dresden.de