Planta Med 2006; 72(10): 945-948
DOI: 10.1055/s-2006-946674
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Inhibition of Protein Tyrosine Phosphatase 1B by Prenylated Isoflavonoids Isolated from the Stem Bark of Erythrina addisoniae [1]

Eun Young Bae1 [2] , MinKyun Na1 [2] , Dieudonné Njamen2 , Joseph Tanyi Mbafor3 , Zacharias Tanee Fomum3 , Long Cui1 , Dong Ho Choung1 , Bo Yeon Kim1 , Won Keun Oh1 , Jong Seog Ahn1
  • 1Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon, Korea
  • 2Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
  • 3Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
Further Information

Publication History

Received: February 28, 2006

Accepted: May 12, 2006

Publication Date:
21 June 2006 (online)

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Abstract

It has been suggested that protein tyrosine phosphatase 1B (PTP1B) inhibitors might be a therapeutic target for the treatment of type 2 diabetes and obesity. A bioassay-guided phytochemical study of the EtOAc extract of the stem bark of Erythrina addisoniae (Leguminosae) resulted in the identification of a new PTP1B inhibitory compound, 5,2′,4′-trihydroxy-6-(γ,γ-dimethylallyl)-2′′′,2′′′-dimethyldihydropyrano[5′′′,6′′′]isoflavanone (6), along with five known prenylated isoflavonoids, orientanol E (1), senegalensin (2), warangalone (3), warangalone 4′-methyl ether (4) and 2,3-dihydroauriculatin (5). Compounds 1, 5 and 6 inhibited PTP1B with IC50 values ranging from 2.6 ± 0.5 to 10.1 ± 0.3 µM. Our results indicate that hydroxylation at both 2′- and 4′-positions in the B-ring and cyclization between a hydroxy group at C-7 and one of the prenyl groups at C-6 or C-8 in the A-ring may be important for activity. Thus, compounds 5 and 6 could be a new class of natural PTP1B inhibitors.

1 Part 47 in the series Erythrina Studies. For part 46 see reference [6]

References

1 Part 47 in the series Erythrina Studies. For part 46 see reference [6]

2 These authors contributed equally to this work.

Won Keun Oh

Korea Research Institute of Bioscience and Biotechnology (KRIBB)

52 Eoun-dong

Yuseong-gu

Daejeon 305-333

Korea

Fax: +82-42-860-4595

Email: wkoh@kribb.re.kr