Regulation and Clinical Significance of Urokinase-Receptor (u-PAR), an Invasion-Related Molecule

Zusammenfassung

Dieser Artikel gibt einen Überblick über den Urokinase-Rezeptor (u-PAR), eines der wichtigsten Moleküle in der tumorassoziierten Proteolyse, Invasion und Metastasierung. Schwerpunkt dieser Zusammenfassung ist die Beschreibung der molekularen Regulation des u-PAR und seine potenzielle klinische und therapeutische Relevanz in gastrointestinalen Karzinomen.

Abstract

This review focuses on the urokinase-receptor (u-PAR), one of the critical molecules mediating tumor-associated proteolysis, invasion, and metastasis, amongst other phenomena associated with tumor progression. Especially, the article gives an overview on the molecular regulation of u-PAR, and its potential clinical and therapeutic relevance in gastrointestinal cancers.

Schlüsselwörter

U-PAR - Transkription - Regulation - gastrointestinales Karzinom

Key words

U-PAR - transcription regulation - colorectal cancer

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