Download PDF
Viszeralchirurgie 2006; 41(1): 1-5
DOI: 10.1055/s-2006-921340
Aktuelle Chirurgie

© Georg Thieme Verlag Stuttgart · New York

Welche Standards braucht die Lymphknoten-Histologie beim kolorektalen Karzinom?

Which Standards are Necessary for the Histological Evaluation of Lymph Nodes in Colorectal Cancer?K. W. Schmid1 , 3 , D. Öfner2
  • 1Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen
  • 2Klinische Abteilung für Viszeral- und Transplantationschirurgie, Medizinische Universität Innsbruck, Österreich
  • 3Mitglied des Westdeutschen Tumorzentrums Essen (WTZE)
Further Information

Publication History

Publication Date:
03 February 2006 (online)

    Permissions and Reprints

Zusammenfassung

Das therapeutische Management des kolorektalen Karzinoms hängt entscheidend vom histologisch evaluierten Lymphknotenstatus ab. Erkenntnisse neuerer Studien weisen darauf hin, dass anstelle einer geforderten Minimalanzahl von zwölf Lymphknoten, die Präparation und histologische Untersuchung aller Lymphknoten eines Operationspräparates anzustreben ist. Dabei ist auch zu beachten, dass, trotz sachgemäßer Aufarbeitung durch den Pathologen, auch Fälle (insbesondere beim Rektumkarzinom) mit deutlich weniger als zwölf Lymphknoten vorkommen können.

Abstract

The detection of lymph node metastases is of vital importance for the therapeutical decision-making in patients with colorectal carcinoma. Due to the results of several recently published studies it seems to be most desirable to identify all lymph nodes rather than follow the recommendation to investigate a minimum number of twelve lymph nodes. However, it has to be noted that, despite a scrupulously exact lymph node recovery by the pathologist, in some cases (particularly in rectal carcinoma) substantially less than twelve lymph nodes may be yielded.

Schlüsselwörter

kolorektales Karzinom - Lymphknoten - Lymphknotenausbeute - Minimalanzahl - Sentinel-Lymphknoten

Key words

colorectal carcinoma - lymph node - lymph node recovery - minimum number - sentinel lymph node

Literatur

  • 1 Moertel C G, Fleming T R, MacDonald J S. et al . Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma.  N Engl J Med. 1990;  322 352-358
    CrossrefPubMedGoogle Scholar
  • 2 Marsoni S. Fluorouracil and folinic acid in colon cancer. IMPACT Investigators.  Lancet. 1995;  345 1582-1583
    CrossrefPubMedGoogle Scholar
  • 3 Hermanek P. [Oncologic suergery/pathologic-anatomic viewpoint]. Langenbecks Arch Chir Suppl Kongressbd 1991; 277-281
    Google Scholar
  • 4 Sobin L H, Wittekind C. TNM Classification of Malignant Tumours. 5th Edition. Wiley-Liss, New York, Chichester, Weinheim, Brisbane, Singapore, Toronto 1997; 66-69
    Google Scholar
  • 5 Nelson H, Petrelli N, Carlin A, Couture J, Fleshman J, Guillem J, Miedema B, Ota D, Sargent D. National Cancer Institute Expert Panel . Guidelines 2000 for colon and rectal cancer surgery.  J Natl Cancer Inst. 2001;  93 583-596
    CrossrefPubMedGoogle Scholar
  • 6 Goldstein N S. Lymph node recoveries from 2 427 pT3 colorectal resection specimens spanning 45 years: recommendations for a minimum number of recovered lymph nodes based on predictive probabilities.  Am J Surg Pathol. 2002;  26 179-189
    CrossrefPubMedGoogle Scholar
  • 7 Thorn C C, Woodcock N P, Scott N. et al . What factors affect lymph node yield in surgery for rectal cancer?.  Colorectal Dis. 2004;  6 356-361
    CrossrefPubMedGoogle Scholar
  • 8 Sobin L H, Wittekind C. TNM Classification of Malignant Tumours. 6th Edition. Wiley-Liss, New York 2002; 72-76
    Google Scholar
  • 9 Wittekind C, Greene F L, Henson D E, Hutter R VP, Sobin L H. TNM Supplement. A Commentary on Uniform Use. Wylie-Liss, New York 2003; 41-43
    Google Scholar
  • 10 Goldstein N S, Turner J R. Pericolonic tumour deposits in patients with T3N+M0 colon adenocarcinomas: a marker for reduced disease-free survival and intraabdominal metastasis.  Cancer. 2000;  88 2228-2238
    CrossrefPubMedGoogle Scholar
  • 11 Harrison J C, Dean P J, El-Zeky F, Vander Zwaag R. From Dukes through Jass. Pathological prognostic indicators in rectal carcinoma.  Hum Pathol. 1994;  25 498-505
    PubMedGoogle Scholar
  • 12 Harrison J C, Dean P J, El-Zeky F, Vander Zwaag R. Impact of the Crohn's like lymphoid reaction on staging of right-sided colon cancer. Results of a multivariate analysis.  Hum Pathol. 1995;  26 31-38
    CrossrefPubMedGoogle Scholar
  • 13 Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften .AWMF online.  www.uni-duesseldorf.de/WWW/AWMF/ll/index.html
    Google Scholar
  • 14 Scott N, Jackson P, al-Jaberi T. et al . Total mesorectal excision and local recurrence: a study of tumour spread in the mesorectum distal to rectal cancer.  Br J Surg. 1995;  82 1031-1033
    CrossrefPubMedGoogle Scholar
  • 15 Heald R J, Husband E M, Ryall R D. The mesorectum in rectal cancer surgery - the clue to pelvic recurrence?.  Br J Surg. 1982;  69 613-616
    CrossrefPubMedGoogle Scholar
  • 16 Wiggers T, Jeekel J, Arends J W. et al . No-touch isolation technique in colon cancer: a controlled prospective trial.  Br J Surg. 1988;  75 409-415
    CrossrefPubMedGoogle Scholar
  • 17 Rouffet F, Hay J M, Vacher B. et al., French Association for Surgical Research . Curative resection for left colonic carcinoma: hemicolectomy vs. segmental colectomy. A prospective, controlled, multicenter trial.  Dis Colon Rectum. 1994;  37 651-659
    CrossrefPubMedGoogle Scholar
  • 18 Martling A, Holm T, Rutqvist L E, Johansson H, Moran B J, Heald R J, Cedermark B. Impact of a surgical training programme on rectal cancer outcomes in Stockholm.  Br J Surg. 2005;  92 225-229
    CrossrefPubMedGoogle Scholar
  • 19 Matzel K E, Merkel S, Hohenberger W. Lokale Therapieprinzipien beim Rektumkarzinom.  Chirurg. 2003;  74 897-904
    CrossrefPubMedGoogle Scholar
  • 20 Zirngibl H, Husemann B, Hermanek P. Intraoperative spillage of tumor cells in surgery for rectal cancer.  Dis Colon Rectum. 1990;  33 610-614
    CrossrefPubMedGoogle Scholar
  • 21 Clinical Outcomes of Surgical Therapy Study Group . A comparison of laparoscopically assisted and open colectomy for colon cancer.  N Engl J Med. 2004;  350 2050-2059
    CrossrefPubMedGoogle Scholar
  • 22 Guillou P J, Quirke P, Thorpe H. et al. nd the MRC CLASICC trial group . Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial.  Lancet. 2005;  365 1718-1726
    CrossrefPubMedGoogle Scholar
  • 23 Caplin S, Cerottini J P, Bosman F T, Constanda M T, Givel J C. For patients with Dukes' B (TNM Stage II) colorectal carcinoma, examination of six or fewer lymph nodes is related to poor prognosis.  Cancer. 1998;  83 666-672
    CrossrefPubMedGoogle Scholar
  • 24 Cianchi F, Palomba A, Boddi V. et al . Lymph node recovery from colorectal tumor specimens: recommendation for a minimum number of lymph nodes to be examined.  World J Surg. 2002;  26 384-389
    CrossrefPubMedGoogle Scholar
  • 25 Tepper J E, O'Connell M J, Niedzwiecki D. et al . Impact of number of nodes retrieved on outcome in patients with rectal cancer.  J Clin Oncol. 2001;  19 157-163
    PubMedGoogle Scholar
  • 26 Pocard M, Panis Y, Malassagne B, Nemeth J, Hautefeuille P, Valleur P. Assessing the effectiveness of mesorectal excision in rectal cancer: prognostic value of the number of lymph nodes found in resected specimens.  Dis Colon Rectum. 1998;  41 839-845
    CrossrefPubMedGoogle Scholar
  • 27 Jass J R. Prognostic factors in rectal cancer.  Eur J Cancer. 1995;  31A 862-863
    PubMedGoogle Scholar
  • 28 Newland R C, Chapuis P H, Smyth E J. The prognostic value of substaging colorectal carcinoma. A prospective study of 1 117 cases with standardized pathology.  Cancer. 1987;  60 852-857
    PubMedGoogle Scholar
  • 29 Cohen A M, Minsky B D, Schilsky R L. Cancers of the gastrointestinal tract: cancer iof the colon. In: DeVita Jr VT, Hellman S, Rosenberg SA (eds). Cancer Principles and Practice of Oncology. Lippincott-Raven, Philadelphia 1997; 1144-1196
    Google Scholar
  • 30 Jass J R, Morson B C. Reporting colorectal cancer.  J Clin Pathol. 1987;  40 1016-1023
    PubMedGoogle Scholar
  • 31 Cohen A M, Tremiterra S, Candela F, Thaler H T, Sigurdson E R. Prognosis of node-positive colon cancer.  Cancer. 1991;  67 1859-1861
    PubMedGoogle Scholar
  • 32 Hida J, Mori N, Kubo R. et al . Metastases from carcinoma of the colon and rectum detected in small lymph nodes by the clearing method.  J Am Coll Surg. 1994;  178 223-228
    PubMedGoogle Scholar
  • 33 Bognel C, Rekacewicz C, Mankarios H. et al . Prognostic value of neural invasion in rectal carcinoma: a multivariate analysis on 339 patients with curative resection.  Eur J Cancer. 1995;  31A 894-898
    PubMedGoogle Scholar
  • 34 Moran M R, James E C, Rothenberger D A, Goldberg S M. Prognostic value of positive lymph nodes in rectal cancer.  Dis Colon Rectum. 1992;  35 579-581
    CrossrefPubMedGoogle Scholar
  • 35 Macdonald J S. Adjuvant therapy of colon cancer.  CA Cancer J Clin. 1999;  49 202-219
    PubMedGoogle Scholar
  • 36 Allegra C J, Paik S, Colangelo L H. et al . Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study.  J Clin Oncol. 2003;  21 241-250
    CrossrefPubMedGoogle Scholar
  • 37 Figueredo A, Charette M L, Maroun J, Brouwers M C, Zuraw L. Adjuvant therapy for stage II colon cancer: a systematic review from the Cancer Care Ontario Program in evidence-based care's gastrointestinal cancer disease site group.  J Clin Oncol. 2004;  22 3395-3407
    CrossrefPubMedGoogle Scholar
  • 38 O'Connell M J, Schaid D J, Ganju V, Cunningham J, Kovach J S, Thibodeau S N. Current status of adjuvant chemotherapy for colorectal cancer. Can molecular markers play a role in predicting prognosis?.  Cancer. 1992;  70 1732-1739
    PubMedGoogle Scholar
  • 39 Frey U H, Alakus H, Wohlschläger J. et al . GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer.  Clin Cancer Res. 2005;  11 5071-5077
    PubMedGoogle Scholar
  • 40 Mulsow J, Winter D C, O'Keane J C, O'Connell P R. Sentinel lymph node mapping in colorectal cancer.  Br J Surg. 2003;  90 659
    CrossrefPubMedGoogle Scholar
  • 41 Bertagnolli M, Miedema B, Redston M. et al . Sentinel node staging of resectable colon cancer: results of a multicenter study.  Ann Surg. 2004;  240 624-628
    PubMedGoogle Scholar
  • 42 Patten L C, Berger D H, Rodriguez-Bigas M. et al . A prospective evaluation of radiocolloid and immunohistochemical staining in colon carcinoma lymphatic mapping.  Cancer. 2004;  100 2104-2109
    CrossrefPubMedGoogle Scholar
  • 43 Stojadinovic A, Allen P J, Protic M, Potter J F, Shriver C D, Nelson J M, Peoples G E. Colon sentinel lymph node mapping: practical surgical applications.  J Am Coll Surg.. 2005;  201 297-313
    CrossrefPubMedGoogle Scholar

Univ.-Prof. Dr. K. W. Schmid

Institut für Pathologie und Neuropathologie · Universitätsklinikum Essen

Hufelandstraße 55

45122 Essen

Germany

Phone: +49/2 01/7 23 28 90

Fax: +49/2 01/7 23 59 26

Email: kw.schmid.pathologie@uni-essen.de

      >