Synthetic Studies on Poison-Frog Alkaloid 261C

Naoki Toyooka; Masashi Kawasaki; Hideo Nemoto; Suresh Awale; Yasuhiro Tezuka; Shigetoshi Kadota

doi:10.1055/s-2005-921911

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Synlett 2005(20): 3109-3110
DOI: 10.1055/s-2005-921911

LETTER

Synthetic Studies on Poison-Frog Alkaloid 261C

Naoki Toyooka*^a, Masashi Kawasaki^b, Hideo Nemoto*^a, Suresh Awale^c, Yasuhiro Tezuka^c, Shigetoshi Kadota^c
^a Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan
e-Mail: toyooka@ms.toyama-mpu.ac.jp;
^b Department of Liberal Arts and Sciences, Faculty of Engineering, Toyama Prefectural University, Kurokawa 5180, Kosugi-Machi, Toyaama 939-0398, Japan
^c Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan

Further Information

Publication History

Received 22 September 2005
Publication Date:
04 November 2005 (online)

Abstract
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Abstract

The synthesis of highly substituted indolizidine core for the synthesis of poison-frog alkaloid 261C has been achieved.

Key words

poison-frog alkaloid 261C - Mantella betsileo - 6,5,5-tricyclic ring system - α7 nicotinic acetylcholine receptors - highly substituted indolizidine core

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