Abstract
Three new compounds, actinidione (1), 3β,29-dihydroxylup-20(30)-en-28-al (2) and 3β-O-trans-caffeoyl-29-hydroxybetulin (3), along with twenty known compounds (4 - 23), were isolated from the leaves and twigs of Clematoclethra actinidioides Maxim. Their structures were determined by analysis of spectral data or comparison with authentic samples. Compounds 1, 2 and 3 exhibited cytotoxicity against Lu-06, N-04 and Bre-04 cell lines with GI50 values of 15.02 - 41.64 μg/mL.
References
-
1 Zhang H Y, Zhang Z H. Handbook of Chinese Traditional Medicine Resources. Beijing; Academic Press 1994: p 234
-
2
Zhang X R, Ding L S, Peng S L, Wang M K.
Chemical constituents from Clematoclethra scandens
.
Tianran Chanwu Yanjiu Yu Kaifa.
2000;
12
38-41
-
3
Zhang X R, Peng S L, Wang M K, Ding L S.
Triterpenoids from Clematoclethra scandens
.
Yaoxue Xuebao.
2001;
36
910-2
-
4
Sinha N K, Seth K K, Pandey V B.
Flavonoids from the flowers of Clerodendron infortunatum
.
Planta Med.
1981;
42
296-8
-
5
Patra A, Chaudhuri S K, Panda S K.
Betulin-3-caffeate from Quercus suber.13C-NMR spectra of some lupenes.
J Nat Prod.
1988;
51
217-20
-
6
Lee Y J, Wu T D.
Total synthesis of kaempferol and methylated kaempferol derivatives.
J Chin Chem Soc.
2001;
48
201-6
-
7
Rancona S, Chabouda A, Darboura N, Comteb G, Barronb D, Raynauda J. et al .
A new C-glycosylxanthone isolated from Davallia solida
.
Phytochemistry.
1999;
52
1677-9
-
8
Shen C C, Chang Y S, Ho L K.
Nuclear magnetic resonance studies of 5,7-dihydroxyflavonoids.
Phytochemistry.
1993;
34
843-5
-
9
Zhang Z Z, Sohly H N, Li X C, Khan S I, Broede S E, Raulli R E. et al .
Phenolic compounds from Nymphaea odorata
.
J Nat Prod.
2003;
66
548-50
-
10
Kazuma K, Noda N, Suzuki M.
Malonylated flavonol glycosides from the petals of Clitoria ternatea
.
Phytochemistry.
2003;
62
229-37
-
11
Tarpley A R, Goldstein J H.
Carbon-13 nuclear magnetic resonance spectra of uracil, thymine, and the 5-halouracils.
J Am Chem Soc.
1971;
93
3573-8
-
12
Sun I C, Wang H K, Kashiwada Y, Shen J K, Cosentino L M, Chen C H. et al .
Anti-AIDS agents 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.
J Med Chem.
1998;
41
4648-57
-
13
Skehan P, Storing R, Scudiero D, Monk A, McMahon J, Visica D.
New colorimetric cytotoxity assay for anticancer-drug-screen.
J Natl Cancer Inst.
1990;
82
1107-12
-
14
Rubinstein L V, Shoemaker R H, Paul K D, Tosini S, Skehan P, Scudiero D A. et al .
Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines.
J Natl Cancer Inst.
1990;
82
1113-8
-
15
Ma Z Z, Yoshio H, Qiu F, Chen Y J, Taro N.
Determination of the absolute stereochemistry of lupane triterpenoids by fucofuranoside method and ORD spectrum.
Tetrahedron Lett.
2004;
45
3261-3
-
16 Huang L, Yu D Q. Application of UV Spectrum in Organic Chemistry. Beijing; Academic Press 2000: p 291
Prof. Dr. Guolin Zhang
Chengdu Institute of Biology
Chinese Academy of Sciences
P. O. Box 416
Chengdu 610041
People’s Republic of China
Phone: +86-28-8522-5401
Fax: +86-28-8522-5401
Email: Zhanggl@cib.ac.cn