Routinemäßige Verwendung hoher inspiratorischer Sauerstoffkonzentrationen - Kontra

Einleitung

„Alle Ding′ sind Gift und nichts ohn′ Gift; allein die Dosis macht das Gift.”

Erst die Dosis unterscheidet das Gift vom Heilmittel: Dies stellte schon der bekannte Arzt und Philosoph Theophrast von Hohenheim (Paracelsus, 1493 - 1541) fest. Selbst der lebensnotwendige Sauerstoff kann in hohen Konzentrationen toxisch sein und Organfunktionen negativ beeinflussen. So schrieb der britische Naturforscher Joseph Priestley (1733 - 1804) kurz nach der Entdeckung des Elements Sauerstoff: „… as a candle burns out much faster in dephlogisticated air (oxygen), so we might live out too fast, and the animal powers be too soon exhausted in this pure kind of air …” [1].

Für das Auftreten von Sauerstoffnebenwirkungen sind generell der inspiratorische Sauerstoffpartialdruck und die Expositionsdauer von entscheidender Bedeutung [2].

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