Zusammenfassung
Die sozioökonomische Bedeutung der koronaren Herzkrankheit und der Wunsch nach nichtinvasiver
Diagnostik möglichst ohne ionisierende Strahlen sind Motive für kardiale Anwendungen
der CT und MRT. Noch vor wenigen Jahren war eine Koronarangiographie mit der CT undenkbar,
heute ist sie bei ausgewählten Fragestellungen bereits Routine. Die MRT ist Referenzstandard
für zahlreiche Funktionsparameter wie Pumpfunktion, Auswurffraktion, Ventrikelvolumina
und Schlagvolumen. Die Vitalität des Herzmuskels wird mit höchster Ortsauflösung zuverlässig
beurteilt. Die Perfusionsuntersuchung ist ebenfalls mit der MRT möglich, muss allerdings
noch validiert werden.
Dieser Artikel gibt eine Übersicht über klinische Fragestellungen, gegenwärtige und
zukünftige Anwendungen sowie Grenzen der kardialen CT und MRT bei der Diagnostik der
koronaren Herzkrankheit.
Abstract
The socioeconomic importance of coronary artery disease and the desire for noninvasive
imaging with less or no ionizing radiation are incentives for computed tomography
(CT) and magnetic resonance imaging (MRI) of the heart. Coronary arteriography with
CT is now routine for selected clinical questions. MRI is the gold standard for analyzing
several functional parameters, such as pump function, ejection fraction, ventricular
volumes and stroke volumes. It is a robust tool for imaging myocardial viability at
high spatial resolution. Moreover, perfusion imaging with MRI is possible, but still
requires validation in larger series. This article reviews clinical applications,
limitations and future aspects of cardiac CT and MRI in the diagnosis of coronary
artery disease.
Key Words
Coronary artery disease - Computed tomography - Magnetic resonance imaging
Literatur
- 1
Fischbach R, Wichter T, Ohnesorge B.
Mehrschicht-CT des Herzens: Untersuchungstechniken und Indikationen.
Radiologie up2date.
2001;
1
48-66
- 2
Lotz J, Miller S, Sandstede J.
Pulmonale und kardiovaskuläre Radiologie.
Radiologie up2date.
2001;
1
21-45
- 3
Ropers D, Moshage W, Daniel W G, Jessl J, Gottwik M, Achenbach S.
Visualization of coronary artery anomalies and their anatomic course by contrast-enhanced
electron beam tomography and three-dimensional reconstruction.
Am J Cardiol.
2001;
87
193-197
- 4
Ropers D, Ulzheimer S, Wenkel E, Baum U, Giesler T, Derlien H, Moshage W, Bautz W,
Daniel W, Kalender W, Achenbach S.
Investigation of coronary artery bypass grafts by multislice spiral computed tomography
with electrocardiographic-gated image reconstruction.
Am J Cardiol.
2001;
88
792-795
- 5
Nieman K, Cademartiri F, Raaijmakers R, Pattynama P, de Feyter P.
Nichtinvasive angiographische Beurteilung von Coronarstents mit dem Multi-Slice-Spiral-CT.
Herz.
2003;
28
388
- 6
Hoffmann M HK, Shi H, Manzke R, Schmid F T, de Vries L, Grass M, Brambs H J, Aschoff A J.
Noninvasive Coronary Angiography with 16-Detector Row CT: Effect of Heart Rate.
Radiology.
2005;
234
86-97
- 7
Ropers D, Baum R, Pohle K. et al .
Detection of coronary artery stenoses with thin-slice multi-detector row spiral computed
tomography and multiplanar reconstruction.
Circulation.
2003;
107
664-666
- 8
Becker C, Knez A.
Past, Present, and Future Perspective of Cardiac Computed Tomography.
J Magn Reson Imaging.
2004;
19
676-685
- 9
Agatston A S, Janowitz W R, Hildner F J, Viamonte M, Detrano R.
Quantification of caronary artery calcium using ultrfast computed tomography.
J Am Coll Cardiol.
1990;
15
827-832
- 10
Kondos G T, Hoff J A, Sevrukov A. et al .
Electron-beam tomography coronary artery calcification on coronary artery calcium
and cardiac events: a 37 months follow-up of 5635 initially asymptomatic low-to-intermediate-risk
adults.
Ciculation.
2003;
107
2571-2576
- 11
O’Malley P, Taylor A, Jackson J, Doherty T, Detrano R.
Prognostic value of coronary electron-beam computed tomography for coronary heart
disease events in asymptomatic populations.
Am J Cardiol.
2000;
85
945-984
- 12
Manning W J, Li W, Edelman R R.
A preliminary report comparing magnetic resonance coronary angiography with conventional
angiography.
N Engl J Med.
1993;
328
828-832
- 13
Li D, Zheng J, Weinmann H J.
Contrast-enhanced MR Imaging of Coronary Arteries: Comparison of Intra- and Extravascular
Contrast Agents in Swine.
Radiology.
2001;
218
670-678
- 14
Slavin G S, Riederer S J, Ehman R L.
Two-dimensional multishot echo-planar coronary MR angiography.
Magn Reson Med.
1998;
40
883-889
- 15
Meyer C H, Hu B S, Nishimura D G. et al .
Fast spiral coronary artery imaging.
Magn Reson Med.
1992;
28
202-213
- 16
Mc C onnell, Ganz P, Selwyn A P, Li W, Edelman R R, Manning W J.
Identification fo anomalous coronary arteries and their anatomic course by magnetic
resonance coronary angiography.
Circulation.
1995;
92
3158-3162
- 17
Post J C, van Rossum A C, Bronzwaer J G. et al .
Magnetic resonance angiography of anomalous coronary arteries: a new gold standard
for delineating the proximal course?.
Circulation.
1995;
92
3163-3171
- 18
Wolff S D, Schwitter J, Coulden R, Friedrich M G, Bluemke D A, Biederman R W, Martin E T,
Lansky A J, Kashanian F, Foo T K, Licato P E, Comeau C R.
Myocardial first-pass perfusion magnetic resonance imaging: a multicenter dose-ranging
study.
Circulation.
2004;
110
732-737
- 19
Ali R aza, Reeves W C, Movahed A.
Pharmacological stress agents for evaluation of ischemic heart disease.
Int J Cardiol.
2001;
81
157-167
- 20
Semelka R C, Tomei E, Wagner S. et al .
Interstudy reproducibility of dimensional and functional measurements between cine
magnetic resonance studies in the morphologically abnormal left ventricle.
Am Heart J.
1990;
119
1367-1373
- 21
Semelka R C, Tomei E, Wagner S. et al .
Normal left ventricular dimensions and function: interstudy reproducibility of measurements
with cine MR imaging.
Radiology.
1990;
174
763-768
- 22
Baer F M, Voth E, Schneider C A, Theissen P, Schicha H, Sechtem U.
Comparison of low-dose dobutamine-gradient-echo magnetic resonance imaging and positron
emission tomography with [18F]fluorodeoxyglucose in patients with chronic coronary
artery disease. A functional and morphological approach to the detection of residual
myocardial viability.
Circulation.
1995;
91
1006-1015
- 23
Grundy S M, Pasternak R, Greenland P, Smith S, Fuster V.
Assessment of Cardiovascular Risk by use of Multiple Risk Factor assessment equations:
A statement for the healthcare professionals from the american heart Association and
the American College of Cardiology.
J Am Coll Cardiol.
1999;
34
1348-1359
- 24
Wilson P W, D’Agostino R B, Levy D, Belanger A M, Silbershatz H, Kannel W B.
Prediction of coronary heart disease using risk factor categories.
Circulation.
1998;
97
1837-1847
- 25
Kim R J, Wu E, Rafael A, Chen E L, Parker M A, Simonetti O, Klocke F J, Conow R O,
Judd R M.
The use of contrast enhanced magnetic resonance imaging to identify reversible myocardial
dysfunction.
N Engl J Med.
2000;
343
1445-1453
- 26
Knollmann F, Pfoh A.
Coronary artery imaging with flat panel computed tomography.
Circulation.
2003;
107
1209
- 27
Morin R L, Gerber T C, McCollough C H.
Radiation Dose in Computed Tomography of the Heart.
Circulation.
2003;
107
917-922
- 28
Stuber M, Botnar R M, Fischer S E. et al .
Preliminary report on in vivo coronary MRA at 3 Tesla in humans.
Mang Reson Med.
2002;
48
425-429
Dr. med. PD Jens Bremerich
Departement Medizinische Radiologie, Universitätsspital Basel
Petersgraben 4 · 4031 Basel · Schweiz
Phone: +41 612652525
Fax: +41 612654354
Email: Jens.Bremerich@unibas.ch