Psychische Erkrankungen und Immunsystem

Zusammenfassung

Die Veränderungen von Immunfunktionen im Zusammenhang mit psychischen Erkrankungen haben im vergangenen Jahrzehnt zunehmende wissenschaftliche Aufmerksamkeit erregt. Inzwischen konnten für die weitere Forschung wegweisende, wenn auch nicht unumstrittene Befunde insbesondere zu Depressionserkrankungen und Schizophrenien erhoben werden. In der vorliegenden Arbeit wird auf diese Befunde im Detail Bezug genommen; zusätzlich werden Beobachtungen bei postraumatischen Belastungsstörungen sowie Panik- und Zwangsstörungen referiert. Auf dieser Grundlage werden Überlegungen zu weiterführenden Forschungsperspektiven angestellt.

Abstract

Immunological alterations in psychiatric disorders have gained increasing scientific attention throughout the last decade. Particularly in two disorders, major depression and schizophrenia, some substantial findings have been reported. Although such results stand not uncontradicted, they nevertheless stimulate current research into the neurobiological underpinnings of these diseases. In this review, immunological dysfunctions in major depression and schizophrenia are described in detail, together with studies on posttraumatic stress disorders, panic- and obsessive-compulsive disorders. Possible future research directions are delineated.

Key words

Immunology - cytokine - depression - posttraumatic stress disorder - anxiety - schizophrenia

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