Semin Liver Dis 2004; 24: 45-53
DOI: 10.1055/s-2004-828678
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Treatment with Interferons (including Pegylated Interferons) in Patients with Hepatitis B

W. Graham Cooksley1
  • 1Department of Medicine, The University of Queensland, Royal Brisbane Hospital, Queensland, Australia
Further Information

Publication History

Publication Date:
11 June 2004 (online)

Studies of 4 to 6 months of treatment with interferon for hepatitis B e antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection have shown clearance of HBeAg to be higher in treated patients than it is in controls by approximately 25%. These results are considerably better than those with antiviral agents. Therefore, the recent European Association for the Study of the Liver (EASL) Consensus Committee recommended the use of interferon α for this condition. Treatment with pegylated interferons in several trials has shown better results still. Lamivudine in combination with interferon, however, did not improve the results at 6 months after the end of therapy. In HBeAg-negative chronic HBV infection, pegylated interferon α is superior to lamivudine, and, again, combination with lamivudine does not improve the results. Side effects in all studies have been tolerable. Thus, these observations in chronic HBV infection, whether HBeAg-positive or HBeAg-negative, suggest an important, even primary, role for pegylated interferon therapy.

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 Professor
Graham Cooksley

Department of Medicine, The University of Queensland

C8 Clinical Sciences Building, Royal Brisbane Hospital

Queensland, Australia 4029

Email: grahamC@qimr.edu.au

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