Zusammenfassung
Die Gefahr schwerer Blutbildveränderungen stellt einen limitierenden Faktor in der
Behandlung mit Clozapin dar. Durch die Entwicklung moderner Antipsychotika der zweiten
Generation ist es heute aber möglich, die positiven Effekte dieser Medikamentengruppe
zu nutzen, ohne die Risiken einer Clozapin-Behandlung eingehen zu müssen. Allerdings
existiert eine Reihe von Kasuistiken, die zeigen, dass auch unter einer Behandlung
mit Antipsychotika der zweiten Generation schwere Blutbildveränderungen auftreten
können. Die vorliegende Arbeit gibt eine Übersicht über die bisher publizierten Fallberichte
und diskutiert die Konsequenzen für die tägliche klinische Praxis.
Abstract
The danger of severe haematological abnormalities limits the use of clozapine in the
treatment of psychoses. The development of modern second generation antipsychotics
such as olanzapine, risperidone, quetiapine, amisulpride, ziprasidone or aripiprazol,
however, makes it possible to use the positive effects of this class of drugs without
the risks of a clozapine treatment. Nevertheless, there are several case reports about
severe haematological abnormalities even during treatment with these second generation
antipsychotics. This review summarises recently published cases and discusses the
consequences for the daily clinical work.
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Prof. Dr. med. Dr. phil. Johannes Thome
Department of Psychiatry · School of Medicine · University of Wales Swansea
Grove Building
Singleton Park
Swansea, SA2 8PP
United Kingdom
Email: j.thome@swan.ac.uk
