Skull Base 2004; 14(1): 39-46
DOI: 10.1055/s-2004-821361
CASE REPORT

Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA

Verrucous Carcinoma of the Temporal Bone: A Wolf Clothed in Wool

Jonathon Michael Pleat1 , Michael Bradley2 , Antonio Orlando3 , Howard Rigby4
  • 1Burns and Reconstructive Surgery Research Trust, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, United Kingdom
  • 2Department of Radiology, Southmead Hospital, North Bristol N.H.S. Trust, Avon, United Kingdom
  • 3Department of Plastic and Reconstructive Surgery, Frenchay Hospital, North Bristol N.H.S. Trust, United Kingdom
  • 4Department of Histopathology, Frenchay Hospital, North Bristol N.H.S. Trust, Avon, United Kingdom
Further Information

Publication History

Publication Date:
23 April 2004 (online)

Verrucous carcinomas are rare tumors that predominantly affect the head and neck region. A paradox of slow, aggressive invasion, apparent lymphadenopathy, yet seemingly bland histopathology, they can beguile unwary clinicians into multiple diagnostic biopsies and regional lymphadenectomy. We report a rare verrucous carcinoma of the temporal bone associated with extensive destruction around the skull base. Placed in the context of the few reports involving this site, extratemporal spread may be associated with a uniformly poor prognosis regardless of the treatment modality. Given new insights into the pathophysiology of this tumor, palliative radiotherapy may be a more appropriate primary treatment compared with the significant local morbidity associated with surgery.

REFERENCES

  • 1 Batsakis J G, Hybels R, Crissman J D, Rice D H. The pathology of head and neck tumours: verrucous carcinoma, part 15.  Head Neck Surg. 1982;  5 29-38
  • 2 Ferlito A, Devaney K O, Rinaldo A, Putzi M J. Papillary squamous cell carcinoma versus verrucous squamous cell carcinoma of the head and neck.  Ann Otol Rhinol Laryngol. 1999;  108 318-322
  • 3 Conley J. Cancer of the middle ear.  Ann Otol Rhinol Laryngol. 1965;  74 555-572
  • 4 Tucker W N. Cancer of the middle ear.  Cancer. 1965;  18 642-650
  • 5 Goodwin W J, Jesse R H. Malignant neoplasms of the external auditory canal and temporal bone.  Arch Otolaryngol. 1980;  106 675-679
  • 6 Sinha P P, Aziz H I. Treatment of carcinoma of the middle ear.  Radiology. 1978;  126 485-487
  • 7 Woodson G E, Jurco S, Alford B R, McGavaran M H. Verrucous carcinoma of the middle ear.  Arch Otolaryngol. 1981;  107 63-65
  • 8 Ferlito A, Recher G. Ackerman's tumour (verrucous carcinoma) of the larynx: a clinicopathological study of 77 cases.  Cancer. 1980;  46 1617-1630
  • 9 Proops D W, Hawke W M, van Nostrand A WP, Harwood A R, Lunan M. Verrucous carcinoma of the ear.  Ann Otol Rhinol Laryngol. 1984;  93 385-388
  • 10 Edelstein D R, Smouha E, Sacks S H, Biller H F, Kaneko M, Parisier S C. Verrucous carcinoma of the temporal bone.  Ann Otol Rhinol Laryngol. 1986;  95 447-453
  • 11 Diengdoh J V, Leeming R D, Shaw M DM. Verrucous carcinoma of the base of the skull.  Br J Neurosurg. 1990;  4 73-76
  • 12 Farrell M L, Dowe A C. Verrucous carcinoma of the temporal bone.  Aust N Z J Surg. 1995;  65 214-216
  • 13 Hagiwara H, Kanazawa T, Ishikawa K et al.. Invasive verrucous carcinoma: a temporal bone histopathology report.  Auris Nasus Larynx. 2000;  27 179-183
  • 14 Ackerman L V. Verrucous carcinoma of the oral cavity.  Surgery. 1948;  23 670-678
  • 15 Kraus F T, Perez-Mesa C. Verrucous carinoma: clinical and pathological study of 105 cases involving oral cavity, larynx and genitalia.  Cancer. 1966;  19 26-38
  • 16 Vandeweyer E F, Sales F, Deraemaecker R. Cutaneous verrucous carcinoma.  Br J Plast Surg. 2001;  54 168-170
  • 17 Noel J C, Peny M O, De Dobbeleer G et al.. p53 Protein overexpression in verrucous carcinoma of the skin.  Dermatology. 1996;  192 12-15
  • 18 Lubbe J, Kormann A, Adams V et al.. HPV-11- and HPV-16-associated oral verrucous carcinoma.  Dermatology. 1996;  192 217-221
  • 19 Takematsu H, Watanabe M, Matsunaga J, Tagami H. Verrucous carcinoma of the face with a massive neutrophil infiltrate: analysis of leucocyte chemotactic activity in the tumour extract.  Clin Exp Dermatol. 1994;  19 26-30
  • 20 Tharp M E, Shidnia H. Radiotherapy in the treatment of verrucous carcinoma of the head and neck.  Laryngoscope. 1995;  105(4 Pt 1) 391-396
  • 21 Ferlito A, Rinaldo A, Mannara G M. Is primary radiotherapy an appropriate option for the treatment of verrucous carcinoma of the head and neck?.  J Laryngol Otol. 1998;  112 132-139
  • 22 Noel J C, Heenen M, Peny M O et al.. Proliferating cell nuclear antigen distribution in verrucous carcinoma of the skin.  Br J Dermatol. 1995;  133 868-873
  • 23 Hiraide F, Inouye T, Ishii T. Primary squamous cell carcinoma of the middle ear invading the cochlea.  Ann Otol Rhinol Laryngol. 1983;  92 290-294

Jonathon Michael PleatM.A. M.R.C.S. 

Burns and Reconstructive Surgery Research Trust, Stoke Mandeville Hospital

Aylesbury, Buckinghamshire

HP21 8AL, United Kingdom

Email: jonathon.pleat@talk21.com

    >