Acute Disseminated Encephalomyelitis and Mucocutaneous Ulcerations

Abstract

A 15-year-old Libyan girl developed typical findings of acute disseminated encephalomyelitis, unveiling characteristic symptoms of Behçet's disease by months. This disease course of neuro-Behçet's disease is quite exceptional in children, and an isolated, high-density MRI lesion of the corpus callosum, like in the present case, has not been described in neuro-Behçet's disease before.

Key words

Acute disseminated encephalomyelitis - Behçet's disease - multiple sclerosis - MRI lesions - corpus callosum - oral and genital ulcers

References

• 1 Akman-Demir G, Serdaroglu P, Tasci B. The Neuro-Behçet Study Group . Clinical patterns of neurological involvement in Behçet's disease: Evaluation of 200 cases.  Brain. 1999;  122 2171-2181
• 2 Banna M, El-Ramahi K. Neurologic involvement in Behçet's disease: Imaging findings in 16 patients.  Am J Neuroradiol. 1991;  12 791-796
• 3 Behçet H. Über rezidivierende, aphthöse, durch ein Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien.  Dermatol Wochenschr. 1937;  105 1152-1157
• 4 Fujikawa S, Suemitsu T. Behçet's disease in children: A nationwide retrospective survey in Japan.  Acta Paediatr Jpn. 1997;  39 285-289
• 5 Gerber S, Biondi A, Dormont D, Wechsler B, Marsault C. Long-term MR follow-up of cerebral lesions in neuro-Behçet's disease.  Neuroradiology. 1996;  38 761-768
• 6 International Study Group for Behçet's Disease . Criteria for the diagnosis of Behçet's disease.  Lancet. 1990;  335 1078-1080
• 7 Kocer N, Islak C, Siva A. et al . CNS involvement in neuro-Behcet syndrome: An MR study.  Am J Neuroradiol. 1999;  20 1015-1024
• 8 Koné-Paut I, Chabrol B, Riss J M, Mancini J, Raybaud C, Garnier J M. Neurologic onset of Behçet's disease: A diagnostic enigma in childhood.  J Child Neurol. 1997;  12 237-241
• 9 Okamoto K, Tokiguchi S, Furusawa T. et al . MR features of disease involving bilateral cerebellar peduncles.  Am J Neuroradiol. 2003;  24 1946-1954
• 10 Picco P, Porfirio B, Gattorno M. et al . MICA gene polymorphism in an Italian paediatric series of juvenile Behçet's disease.  Int J Mol Med. 2002;  10 575-578