Neuropediatrics 2004; 35(4): 253-254
DOI: 10.1055/s-2004-820995
Short Communication

Georg Thieme Verlag KG Stuttgart · New York

Acute Disseminated Encephalomyelitis and Mucocutaneous Ulcerations

G. M. Lackmann1 , S. Lyding2 , A. Scherer3 , T. Niehues2
  • 1Outpatient Paediatric Office, Hamburg, Germany
  • 2Department of Paediatric Oncology, Haematology and Immunology, Division of Paediatric Immunology and Rheumatology, Heinrich-Heine University, Düsseldorf, Germany
  • 3Institute of Diagnostic Radiology, Heinrich-Heine University, Düsseldorf, Germany
Further Information

Publication History

Received: October 12, 2003

Accepted after Revision: April 9, 2004

Publication Date:
10 August 2004 (online)

Abstract

A 15-year-old Libyan girl developed typical findings of acute disseminated encephalomyelitis, unveiling characteristic symptoms of Behçet's disease by months. This disease course of neuro-Behçet's disease is quite exceptional in children, and an isolated, high-density MRI lesion of the corpus callosum, like in the present case, has not been described in neuro-Behçet's disease before.

References

  • 1 Akman-Demir G, Serdaroglu P, Tasci B. The Neuro-Behçet Study Group . Clinical patterns of neurological involvement in Behçet's disease: Evaluation of 200 cases.  Brain. 1999;  122 2171-2181
  • 2 Banna M, El-Ramahi K. Neurologic involvement in Behçet's disease: Imaging findings in 16 patients.  Am J Neuroradiol. 1991;  12 791-796
  • 3 Behçet H. Über rezidivierende, aphthöse, durch ein Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien.  Dermatol Wochenschr. 1937;  105 1152-1157
  • 4 Fujikawa S, Suemitsu T. Behçet's disease in children: A nationwide retrospective survey in Japan.  Acta Paediatr Jpn. 1997;  39 285-289
  • 5 Gerber S, Biondi A, Dormont D, Wechsler B, Marsault C. Long-term MR follow-up of cerebral lesions in neuro-Behçet's disease.  Neuroradiology. 1996;  38 761-768
  • 6 International Study Group for Behçet's Disease . Criteria for the diagnosis of Behçet's disease.  Lancet. 1990;  335 1078-1080
  • 7 Kocer N, Islak C, Siva A. et al . CNS involvement in neuro-Behcet syndrome: An MR study.  Am J Neuroradiol. 1999;  20 1015-1024
  • 8 Koné-Paut I, Chabrol B, Riss J M, Mancini J, Raybaud C, Garnier J M. Neurologic onset of Behçet's disease: A diagnostic enigma in childhood.  J Child Neurol. 1997;  12 237-241
  • 9 Okamoto K, Tokiguchi S, Furusawa T. et al . MR features of disease involving bilateral cerebellar peduncles.  Am J Neuroradiol. 2003;  24 1946-1954
  • 10 Picco P, Porfirio B, Gattorno M. et al . MICA gene polymorphism in an Italian paediatric series of juvenile Behçet's disease.  Int J Mol Med. 2002;  10 575-578

Priv.-Doz. Dr. med. Gerd-Michael Lackmann

Reinstorfweg 10 a

21107 Hamburg

Germany

Email: GMLackmann.Praxis@t-online.de