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Exp Clin Endocrinol Diabetes 2004; 112(6): 333-337
DOI: 10.1055/s-2004-820912
Case Report

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Pregnancy in a Woman Suffering from Type 1 Diabetes Associated with Addison's Disease and Hashimoto's Thyroiditis (Fully Developed Autoimmune Polyglandular Syndrome Type 2)

K. Stechova1 , D. Bartaskova2 , M. Mrstinova3 , M. Cerny4 , M. Snajderova1 , O. Cinek1 , Z. Sumnik1 , J. Vavrinec1
  • 12nd Department of Paediatrics, University Hospital Motol in Prague, Czech Republic
  • 2Department of Internal Medicine, University Hospital Motol in Prague, Czech Republic
  • 3Department of Gynaecology and Obstetrics, University Hospital Motol in Prague, Czech Republic
  • 4Department of Gynaecology and Obstetrics, NICU, University Hospital Motol in Prague, Czech Republic
Further Information

Publication History

Received: June 23, 2003 First decision: August 20, 2003

Accepted: October 6, 2003

Publication Date:
24 June 2004 (online)

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Abstract

In this article the pregnancy of a woman suffering from the complete triad typical of Autoimmune Polyglandular Syndrome Type 2 (Addison's disease + type 1 diabetes + Hashimoto's thyroiditis) is reported.

By using insulin pump therapy with insulin lispro, it was possible to balance diabetes control with changes of steroid replacement therapy. Pregnancy was uneventful until week 27, when signs of preeclampsia occurred. The boy was born without difficulty at gestational age 37 weeks by planned cesarean section but signs of diabetic fetopathy (macrosomia, hypoglycaemia and hypocalcaemia) were expressed. He required a short course of hydrocortisone therapy. He made a good and rapid recovery. The mother made a good post-operative recovery too, but 4 months after the delivery microalbuminuria as well as mild hyperuricemia are still present.

Interdisciplinary approach and very careful observation of the mother as well as of the child enabled successful outcome of this highly risky pregnancy.

Key words

Autoimmune polyglandular syndrome type 2 - pregnancy - type 1 diabetes

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M. D., PhD Katerina Stechova

2nd Department of Paediatrics
University Hospital Motol in Prague

V Uvalu 84

Prague 5 - Motol, 15006

Czech Republic

Phone: + 420224432200

Fax: + 42 02 24 43 22 20

Email: KaterinaStechova@seznam.cz