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Handchir Mikrochir Plast Chir 2004; 36(1): 1-7
DOI: 10.1055/s-2004-820870
Übersichtsartikel

Georg Thieme Verlag Stuttgart · New York

Alternatives to Autologous Nerve Grafts

Alternativen zu autologen NerventransplantatenG. Lundborg1
  • 1Department of Hand Surgery, Malmö University Hospital, Malmö, Sweden
Further Information

Publication History

Eingang des Manuskriptes: July 10, 2003

Angenommen: October 31, 2003

Publication Date:
13 April 2004 (online)

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Zusammenfassung

Der Einsatz autologer Nerventransplantate zur Überbrückung von Nervendefekten verlangt die Verwendung von gesunden Nerven. Die Entwicklung von Alternativen zum autologen Nerventransplantat ist daher gut begründet. Derartige „künstliche Nerven“ können in einem Tissue-Engineering-Verfahren auf der Basis des Einsatzes von Stroma/Matrix/Träger einerseits und Zellen und neurotrope Substanzen andererseits hergestellt werden. Dabei kann der Träger aus synthetischem oder aus biologischem Material bestehen und resorbierbar oder nicht-resorbierbar sein. Dabei ist ein Zusammenwirken mit vorkultivierten oder frisch gewonnenen Schwannschen Zellen erforderlich. Die neurotropen Substanzen, die die axonale Aussprossung stimulieren, können dabei entweder in den Träger inkorporiert oder mit den Stromazellen eingebracht werden. Bisher wurden über Tissue-Engineering hergestellte Nervenleitbahnen hauptsächlich für experimentelle Zwecke in Tierexperimenten eingesetzt. Es wächst jedoch gegenwärtig die Erfahrung für den klinischen Einsatz von Alternativen zum Nerventransplantat, bei denen es sich hauptsächlich um Röhren aus Silikon oder Polyglykolsäure (PGA), Venen, Kollagen und Basalschicht von Muskeln handelt.

Abstract

The use of autologous nerve grafts for bridging defects in nerve continuity requires the sacrifice of healthy nerves. Development of alternatives to autologous nerve grafts is therefore well motivated. Such “bioartificial nerve grafts” can be tissue-engineered on the basis of the use of a stroma/matrix/scaffold acting in concert with cells and neurotrophic factors. Such a scaffold can be of synthetic or biological nature and can be resorbable or non-resorbable. It should act together with Schwann cells which can be pre-cultured or acutely dissociated. Neurotrophic factors, stimulating axonal growth, can be incorporated in the scaffold and can also be supplied by cells which are seeded into the stroma. So far, tissue-engineered nerve conduits have been used mainly for experimental purposes in experimental animals. However, an increasing amount of experience from the clinical use of alternatives to nerve grafts now exists, mainly tubes made of silicone or poly-glycolic acid (PGA), veins, collagen and muscle basal laminae.

Schlüsselwörter

Nerven-Konduit - Nerventransplantat - künstliches Nerventransplantat

Key words

Nerve conduit - nerve graft - transplantation - bioartificial nerve graft

References

  • 1 Aebischer P, Guenard V, Valentini R F. The morphology of regenerating peripheral nerves is modulated by the surface microgeometry of polymeric guidance channels.  Brain Res. 1990;  531 211-218
    CrossrefPubMedGoogle Scholar
  • 2 Ahmed Z, Brown R A, Ljungberg C, Wiberg M, Terenghi G. Nerve growth factor enhances peripheral nerve regeneration in non-human primates.  Scand J Plast Reconstr Surg Hand Surg. 1999;  33 393-401
    CrossrefPubMedGoogle Scholar
  • 3 Ansselin A D, Fink T, Davey D F. Peripheral nerve regeneration through nerve guides seeded with adult Schwann cells.  Neuropathol Appl Neurobiol. 1997;  23 387-398
    CrossrefPubMedGoogle Scholar
  • 4 Arai T, Kanje M, Lundborg G, Sondell M, Liu X L, Dahlin L B. Axonal outgrowth in muscle grafts made acellular by chemical extraction.  Restor Neurol Neurosci. 2000;  17 165-174
    PubMedGoogle Scholar
  • 5 Archibald S J, Shefner J, Krarup C, Madison R D. Monkey median nerve repaired by nerve graft or collagen nerve guide tube.  J Neurosci. 1995;  15 4109-4123
    PubMedGoogle Scholar
  • 6 Bailey S B, Eichler M E, Villadiego A, Rich K M. The influence of fibronectin and laminin during Schwann cell migration and peripheral nerve regeneration through silicon chambers.  J Neurocytol. 1993;  22 176-184
    CrossrefPubMedGoogle Scholar
  • 7 Baron-Van Evercooren A, Kleinman H K, Ohno S, Marangos P, Schwarts J P, Dubois-Dalcq M E. Nerve growth factor, laminin and fibronectin promote neuritic growth in human fetal sensory ganglia cultures.  J Neurosci Res. 1982;  8 179-194
    CrossrefPubMedGoogle Scholar
  • 8 Battiston B, Tos P, Cushway T R, Geuna S. Nerve repair by means of vein filled with muscle grafts I. Clinical results.  Microsurgery. 2000;  20 32-36
    CrossrefPubMedGoogle Scholar
  • 9 Battiston B, Tos P, Geuna S, Giacobini-Robecchi M G, Guglielmone R. Nerve repair by means of vein filled with muscle grafts. II. Morphological analysis of regeneration.  Microsurgery. 2000;  20 37-41
    CrossrefPubMedGoogle Scholar
  • 10 Bergman S, Widerberg A, Danielsen N, Lundborg G, Dahlin L B. Nerve regeneration in nerve grafts conditioned by vibration exposure.  Restor Neurol Neurosci. 1995;  7 165-169
    PubMedGoogle Scholar
  • 11 Brandt J, Dahlin L B, Kanje M, Lundborg G. Spatiotemporal progress of nerve regeneration in a tendon autograft used for bridging a peripheral nerve defect.  Exp Neurol. 1999;  160 386-393
    CrossrefPubMedGoogle Scholar
  • 12 Brandt J, Dahlin L B, Kanje M, Lundborg G. Functional recovery in a tendon autograft used to bridge a peripheral nerve defect.  Scand J Plast Reconstr Surg Hand Surg. 2002;  36 2-8
    CrossrefPubMedGoogle Scholar
  • 13 Brandt J, Dahlin L B, Lundborg G. Autologous tendons used as grafts for bridging peripheral nerve defects.  J Hand Surg [Br]. 1999;  24 284-290
    CrossrefPubMedGoogle Scholar
  • 14 Brandt J, Nishiura Y, Kanje M, Lundborg G, Dahlin L B. A Schwann cell seeded tendon autograft used for peripheral nerve repair. VIIth FESSH Congress Amsterdam. 2002
    Google Scholar
  • 15 Buti M, Verdu E, Labrador R O, Vilches J J, Fores J, Navarro X. Influence of physical parameters of nerve chambers on peripheral nerve regeneration and reinnervation.  Exp Neurol. 1996;  137 26-33
    CrossrefPubMedGoogle Scholar
  • 16 Calder J S, Green C J. Nerve-muscle sandwich grafts: the importance of Schwann cells in peripheral nerve regeneration through muscle basal lamina conduits.  J Hand Surg [Br]. 1995;  20 423-428
    PubMedGoogle Scholar
  • 17 Chiu D T. Autogenous venous nerve conduits. A review.  Hand Clin. 1999;  15 667-671
    PubMedGoogle Scholar
  • 18 Chiu D T, Lovelace R E, Yu L T, Wolff M, Stengel S, Middleton L, Janecka I P, Krizek T J. Comparative electrophysiologic evaluation of nerve grafts and autogenous vein grafts as nerve conduits: an experimental study.  J Reconstr Microsurg. 1988;  4 303-309 311-312
    PubMedGoogle Scholar
  • 19 Chiu D T, Strauch B. A prospective clinical evaluation of autogenous vein grafts used as a nerve conduit for distal sensory nerve defects of 3 cm or less.  Plast Reconstr Surg. 1990;  86 928-934
    CrossrefPubMedGoogle Scholar
  • 20 Chiu D TW, Janecka I, Krizek T J, Wolff M, Lovelace R E. Autogenous vein graft as a conduit for nerve regeneration.  Surgery. 1982;  91 226-233
    PubMedGoogle Scholar
  • 21 Crawley W A, Dellon A L. Inferior alveolar nerve reconstruction with a polyglycolic acid bioabsorbable nerve conduit.  Plast Reconstr Surg. 1992;  90 300-302
    CrossrefPubMedGoogle Scholar
  • 22 Dahlin L, Lundborg G. Bridging defects in nerve continuity: influence of variations in synthetic fiber composition.  J Mater Sci Mat Med. 1999;  10 549-553
    PubMedGoogle Scholar
  • 23 Dahlin L B, Lundborg G. Experimental nerve grafting - towards future solutions of a clinical problem.  J Hand Surg [Br]. 1998;  23 165-173
    PubMedGoogle Scholar
  • 24 Dahlin L B, Zhao Q, Bjursten L M. Nerve regeneration in silicone tubes: distribution of macrophages and interleukin-1β in the formed fibrin matrix.  Restor Neurol Neurosci. 1995;  8 199-203
    PubMedGoogle Scholar
  • 25 Danielsen N, Dahlin L B, Thomsen P. Inflammatory cells and mediators in the silicone chamber model for nerve regeneration.  Biomaterials. 1993;  14 1180-1185
    CrossrefPubMedGoogle Scholar
  • 26 Danielsen N, Kerns J M, Holmquist B, Zhao Q, Lundborg G, Kanje M. Pre-degenerated nerve grafts enhance regeneration by shortening the initial delay period.  Brain Res. 1994;  666 250-254
    CrossrefPubMedGoogle Scholar
  • 27 Danielsen N, Pettman B, Vahlsing H L, Manthorpe M, Varon S. Fibroblast growth factor effects on peripheral nerve regeneration in a silicone chamber model.  J Neurosci Res. 1988;  20 320-330
    CrossrefPubMedGoogle Scholar
  • 28 Danielsen N, Varon S. Characterization of neurotrophic activity in the silicone chamber model for nerve regeneration.  J Reconstr Microsurg. 1995;  11 231-235
    PubMedGoogle Scholar
  • 29 Danielson P, Dahlin L B, Povlsen B. Increased axonal outgrowth following a crush injury to the rat sciatic nerve by encapsulating the zone of regeneration in a silicone tube.  Exp Neurol. 1996;  139 238-243
    CrossrefPubMedGoogle Scholar
  • 30 Dellon A L, Mackinnon S E. An alternative to the classical nerve graft for the management of the short nerve gap.  Plast Reconstr Surg. 1988;  82 849-856
    CrossrefPubMedGoogle Scholar
  • 31 Fansa H, Keilhoff G, Forster G, Seidel B, Wolf G, Schneider W. Acellular muscle with Schwann-cell implantation: an alternative biologic nerve conduit.  J Reconstr Microsurg. 1999;  15 531-537
    PubMedGoogle Scholar
  • 32 Fawcett J W, Keynes R J. Muscle basal lamina: a new graft material for peripheral nerve repair.  J Neurosurg. 1986;  65 354-363
    CrossrefPubMedGoogle Scholar
  • 33 Feneley M R, Fawcett J W, Keynes R J. The role of Schwann cells in the regeneration of peripheral nerve axons through muscle basal lamina grafts.  Exp Neurol. 1991;  114 275-285
    CrossrefPubMedGoogle Scholar
  • 34 Foidart-Dessalle M, Dubuisson A, Lejeune A, Severyns A, Manassis Y, Delree P, Crielaard J M, Bassleer R, Lejeune G. Sciatic nerve regeneration through venous or nervous grafts in the rat.  Exp Neurol. 1997;  148 236-246
    CrossrefPubMedGoogle Scholar
  • 35 Fornaro M, Tos P, Geuna S, Giacobini-Robecchi M G, Battiston B. Confocal imaging of Schwann-cell migration along muscle-vein combined grafts used to bridge nerve defects in the rat.  Microsurgery. 2001;  21 153-155
    CrossrefPubMedGoogle Scholar
  • 36 Geuna S, Tos P, Battiston B, Guglielmone R, Giacobini-Robecchi M G. Morphological analysis of peripheral nerve regenerated by means of vein grafts filled with fresh skeletal muscle.  Anat Embryol (Berl). 2000;  201 475-482
    CrossrefPubMedGoogle Scholar
  • 37 Geuna S, Tos P, Battiston B, Guglielmone R, Giacobini-Robecchi M G. A stereological study of long-term regeneration of rat severed sciatic nerve repaired by means of muscle-vein-combined grafts.  Ital J Anat Embryol. 2000;  105 65-73
    PubMedGoogle Scholar
  • 38 Glasby M A. Interposed muscle grafts in nerve repair in the hand: an experimental basis for future clinical use.  World J Surg. 1991;  15 501-510
    CrossrefPubMedGoogle Scholar
  • 39 Glasby M A, Carrick M J, Hems T EJ. Freeze-thawed skeletal muscle autografts used for brachial plexus repair in the non-human primate.  J Hand Surg [Br]. 1992;  17 526-535
    PubMedGoogle Scholar
  • 40 Glasby M A, Gschmeissner S E, Huang C-H, De Souza B A. Degenerated muscle grafts used for peripheral nerve repair in primates.  J Hand Surg [Br]. 1986;  11 347-351
    CrossrefPubMedGoogle Scholar
  • 41 Glasby M A, Gschmeissner S G, Hitchcock R JI, Huang C L-H. The dependence of nerve regeneration through muscle grafts in the rat on the availability and orientation of basement membrane.  J Neurocytol. 1986;  15 497-510
    CrossrefPubMedGoogle Scholar
  • 42 Gomez N, Cuadras J, Buti M, Navarro X. Histologic assessment of sciatic nerve regeneration following resection and graft or tube repair in the mouse.  Rest Neurol Neurosci. 1996;  10 187-196
    PubMedGoogle Scholar
  • 43 Gschmeissner S E, Gattuso J M, Glasby M A, Huang C L-H. Functional reinnervation of muscles after nerve repair with muscle grafts. Demonstration using a new combined stain.  Neuro-Orthopedics. 1988;  5 1-9
    PubMedGoogle Scholar
  • 44 Guénard V, Kleitman N, Morrissey T K, Bunge R P, Aebischer P. Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration.  J Neurosci. 1992;  12 3310-3320
    PubMedGoogle Scholar
  • 45 Gulati A K. Peripheral nerve regeneration through short- and long-term degenerated nerve transplants.  Brain Res. 1996;  742 265-270
    CrossrefPubMedGoogle Scholar
  • 46 Haapaniemi T, Nylander G, Kanje M, Dahlin L B. Hyperbaric oxygen treatment enhances regeneration of the rat sciatic nerve.  Exp Neurol. 1998;  149 433-438
    CrossrefPubMedGoogle Scholar
  • 47 Hazari A, Johansson-Ruden G, Junemo-Bostrom K, Ljungberg C, Terenghi G, Green C, Wiberg M. A new resorbable wrap-around implant as an alternative nerve repair technique.  J Hand Surg [Br]. 1999;  24 291-295
    CrossrefPubMedGoogle Scholar
  • 48 Hazari A, Wiberg M, Johansson-Ruden G, Green C, Terenghi G. A resorbable nerve conduit as an alternative to nerve autograft in nerve gap repair.  Br J Plast Surg. 1999;  52 653-657
    CrossrefPubMedGoogle Scholar
  • 49 Hems T EJ, Glasby M A. The limit of graft length in the experimental use of muscle grafts for nerve repair.  J Hand Surg [Br]. 1993;  18 165-170
    CrossrefPubMedGoogle Scholar
  • 50 Ide C, Tohyama K, Yokota R, Nitatori T, Onodera S. Schwann cell basal lamina and nerve regeneration.  Brain Res. 1983;  288 61-75
    CrossrefPubMedGoogle Scholar
  • 51 Jenq C B, Coggeshall R E. Nerve regeneration through holey silicone tubes.  Brain Res. 1985;  361 233-241
    CrossrefPubMedGoogle Scholar
  • 52 Kanje M, Stenberg L, Ahlin A, Dahlin L B. Activation of non-neuronal cells in the rat sciatic nerve in response to inflammation caused by implanted silicone tubes.  Rest Neurol Neurosci. 1995;  8 181-187
    PubMedGoogle Scholar
  • 53 Kauppila T, Jyväsjärvi E, Huopaniemi T, Hujanen E, Liesi P. A laminin graft replaces neurorrhaphy in the restorative surgery of the rat sciatic nerve.  Exp Neurol. 1993;  123 181-191
    CrossrefPubMedGoogle Scholar
  • 54 Keynes R J, Hopkins W G, Huang C-H. Regeneration of mouse peripheral nerves in degenerating skeletal muscle: guidance by residual muscle fibre basement membranes.  Brain Res. 1984;  295 275-281
    CrossrefPubMedGoogle Scholar
  • 55 Kim D H, Connolly S E, Kline D G, Voorhies R M, Smith A, Powell M, Yoes T, Daniloff J K. Labeled Schwann cell transplants versus sural nerve grafts in nerve repair.  J Neurosurg. 1994;  80 254-260
    PubMedGoogle Scholar
  • 56 Kim D H, Connolly S E, Zhao S, Beuerman R W, Voorhies R M, Kline D G. Comparison of macropore, semipermeable and nonpermeable collagen conduits in nerve repair.  J Reconstr Microsurg. 1993;  9 415-420
    Article in Thieme ConnectPubMedGoogle Scholar
  • 57 Kljavin I J, Madison R D. Peripheral nerve regeneration within tubular prostheses: effects of laminin and collagen matrices on cellular ingrowth.  Cells & Materials. 1991;  1 17-28
    PubMedGoogle Scholar
  • 58 Krarup C, Archibald S J, Madison R D. Factors that influence peripheral nerve regeneration: an electrophysiological study of the monkey median nerve.  Ann Neurol. 2002;  51 69-81
    CrossrefPubMedGoogle Scholar
  • 59 Labrador R O, Buti M, Navarro X. Influence of collagen and laminin gels concentration on nerve regeneration after resection and tube repair.  Exp Neurol. 1998;  149 243-252
    CrossrefPubMedGoogle Scholar
  • 60 Levi A D, Sonntag V K, Dickman C, Mather J, Li R H, Cordoba S C, Bichard B, Berens M. The role of cultured Schwann cell grafts in the repair of gaps within the peripheral nervous system of primates.  Exp Neurol. 1997;  143 25-36
    CrossrefPubMedGoogle Scholar
  • 61 Li S T, Archibald S J, Krarup C, Madison R D. Peripheral nerve repair with collagen conduits.  Clin Mater. 1992;  9 195-200
    CrossrefPubMedGoogle Scholar
  • 62 Liu X L, Arai T, Sondell M, Lundborg G, Kanje M, Dahlin L B. Use of chemically extracted muscle grafts to repair extended nerve defects in rats.  Scand J Plast Reconstr Surg Hand Surg. 2001;  35 337-345
    CrossrefPubMedGoogle Scholar
  • 63 Ljungberg C, Novikov L, Kellerth J, Ebendal T, Wiberg M. The neurotrophins NGF and NT-3 reduce sensory neuronal loss in adult rat after peripheral nerve lesion.  Neurosc Letter. 1999;  262 29-32
    PubMedGoogle Scholar
  • 64 Longo F M, Hayman E G, Davis G E, Ruoslahti E, Engvall E, Manthorpe M, Varon S. Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers.  Brain Res. 1984;  309 105-117
    CrossrefPubMedGoogle Scholar
  • 65 Longo F M, Manthorpe M, Skaper S D, Lundborg G, Varon S. Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers.  Brain Res. 1983;  261 109-117
    CrossrefPubMedGoogle Scholar
  • 66 Longo F M, Skaper S D, Manthorpe M, Williams L R, Lundborg G, Varon S. Temporal changes of neuronotrophic activities accumulating in vivo within nerve regeneration chambers.  Exp Neurol. 1983;  81 756-769
    CrossrefPubMedGoogle Scholar
  • 67 Lundborg G. Nerve Injury and Repair. Edinburgh; Churchill Livingstone 1988
    Google Scholar
  • 68 Lundborg G. A 25-year perspective of peripheral nerve surgery: Evolving neuroscientific concepts and clinical significance.  J Hand Surg [Am]. 2000;  25 391-414
    CrossrefPubMedGoogle Scholar
  • 69 Lundborg G, Dahlin L, Kanje M, Terada N, Dohi D. A new type of bioartificial nerve graft for bridging of extended defects in nerve continuity.  J Hand Surg [Br]. 1997;  22 299-303
    PubMedGoogle Scholar
  • 70 Lundborg G, Dahlin L B, Danielsen N. Ulnar nerve repair by the silicone chamber technique: Case report.  Scand J Plast Reconstr Hand Surg. 1991;  25 79-82
    CrossrefPubMedGoogle Scholar
  • 71 Lundborg G, Dahlin L B, Danielsen N, Gelberman R H, Longo F M, Powell H C, Varon S. Nerve regeneration in silicone chambers: influence of gap length and of distal stump components.  Exp Neurol. 1982;  76 361-375
    CrossrefPubMedGoogle Scholar
  • 72 Lundborg G, Hansson H A. Regeneration of peripheral nerve through a preformed tissue space. Preliminary observations on the reorganization of regenerating nerve fibres and perineurium.  Brain Res. 1979;  178 573-576
    CrossrefPubMedGoogle Scholar
  • 73 Lundborg G, Hansson H A. Nerve regeneration through preformed pseudosynovial tubes: A preliminary report of a new experimental model for studying the regeneration and reorganization capacity of peripheral nerve tissue.  J Hand Surg [Am]. 1980;  5 35-38
    PubMedGoogle Scholar
  • 74 Lundborg G, Kanje M. Bioartificial nerve grafts - a prototype.  Scand J Plast Reconstr Hand Surg. 1996;  30 105-110
    PubMedGoogle Scholar
  • 75 Lundborg G, Longo F M, Varon S. Nerve regeneration model and trophic factors in vivo.  Brain Res. 1982;  232 157-161
    CrossrefPubMedGoogle Scholar
  • 76 Lundborg G, Rosén B, Abrahamsson S O, Dahlin L B, Danielsen N. Tubular repair of the median nerve in the human forearm. Preliminary findings.  J Hand Surg [Br]. 1994;  19 273-276
    CrossrefPubMedGoogle Scholar
  • 77 Lundborg G, Rosén B, Dahlin L, Danielsen N, Holmberg J. Tubular versus conventional repair of median and ulnar nerves in the human forearm: early results from a prospective, randomized, clinical study.  J Hand Surg [Am]. 1997;  22 99-106
    PubMedGoogle Scholar
  • 78 Lundborg G, Rosén B, Dahlin L, Holmberg J, Rosén I. Tubular repair of the median and ulnar nerve in the human forearm: a five-year follow-up.  J Hand Surg [Br]. (in press); 
    PubMedGoogle Scholar
  • 79 Mackinnon S E, Dellon A L. Clinical nerve reconstruction with a bioabsorbable polyglycolic acid tube.  Plast Reconstr Surg. 1990;  85 419-424
    CrossrefPubMedGoogle Scholar
  • 80 Mackinnon S E, Dellon A L. A study of nerve regeneration across synthetic (Maxon) and biologic (collagen) nerve conduits for nerve gaps up to 5 cm in the primate.  J Reconstr Microsurg. 1990;  6 117-121
    Article in Thieme ConnectPubMedGoogle Scholar
  • 81 Madison R D, Archiblad S J. Potential value of synthetic tubes for nerve repair. Wilkins RH, Rengachary SS Neurosurgery. 2nd ed. New York; McGraw-Hill 1996
    Google Scholar
  • 82 Madison R D, Da Silva C, Dikkes P, Sidman R L, Chiu T H. Peripheral nerve regeneration with entubulation repair: Comparison of biodegradable nerve guides versus polyethylene tubes and the effects of a laminin-containing gel.  Exp Neurol. 1987;  95 378-390
    CrossrefPubMedGoogle Scholar
  • 83 Madison R D, Da Silva C F, Dikkes P, Chiu T H, Sidman R L. Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel.  Exp Neurol. 1985;  88 767-772
    CrossrefPubMedGoogle Scholar
  • 84 Madison R D, DaSilva C F, Dikkes P. Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses.  Brain Res. 1988;  447 325-334
    CrossrefPubMedGoogle Scholar
  • 85 Millesi H. Techniques for nerve grafting.  Hand Clinics. 2000;  16 73-91
    PubMedGoogle Scholar
  • 86 Millesi H, Meissl G, Berger A. The interfascicular nerve grafting of the median and ulnar nerves.  J Bone Joint Surg [Am]. 1972;  54 727-750
    PubMedGoogle Scholar
  • 87 Millesi H, Meissl G, Berger A. Further experience with interfascicular grafting of the median, ulnar and radial nerves.  J Bone Joint Surg [Am]. 1976;  58 209-217
    PubMedGoogle Scholar
  • 88 Molander H, Engkvist O, Hägglund J, Olsson Y, Torebjörk E. Nerve repair using a polyglactin tube and nerve graft: An experimental study in the rabbit.  Biomaterials. 1983;  4 276-280
    CrossrefPubMedGoogle Scholar
  • 89 Molander H, Olsson Y, Engkvist O, Bowald S, Eriksson I. Regeneration of peripheral nerve through a polyglactin tube.  Muscle Nerve. 1982;  5 54-57
    CrossrefPubMedGoogle Scholar
  • 90 Mosahebi A, Fuller P, Wiberg M, Terenghi G. Effect of allogeneic Schwann cell transplantation on peripheral nerve regeneration.  Exp Neurol. 2002;  173 213-223
    CrossrefPubMedGoogle Scholar
  • 91 Müller H W, Williams L R, Varon S. Nerve regeneration chamber: evaluation of exogenous agents applied by multiple injections.  Brain Res. 1987;  413 320-326
    CrossrefPubMedGoogle Scholar
  • 92 Navarro X, Rodriguez F J, Labrador R O, Buti M, Ceballos D, Gomez N, Cuadras J, Perego G. Peripheral nerve regeneration through bioresorbable and durable nerve guides.  J Periph Nerv Syst. 1996;  1 53-64
    PubMedGoogle Scholar
  • 93 Navarro X, Udina E, Ceballos D, Gold B G. Effects of FK506 on nerve regeneration and reinnervation after graft or tube repair of long nerve gaps.  Muscle Nerve. 2001;  24 905-915
    CrossrefPubMedGoogle Scholar
  • 94 Navarro X, Verdu E, Buti M. Comparison of regenerative and reinnervating capabilities of different functional types of nerve fibers.  Exp Neurol. 1994;  129 217-224
    CrossrefPubMedGoogle Scholar
  • 95 Nishiura Y, Kanje M, Brandt J, Lundborg G, Nilsson A, Dahlin L B. Addition of Schwann cells to teased tendon grafts and acellular muscle grafts improves nerve regeneration. Society for Neuroscience San Diego, Nov 10 - 15. 2001
    Google Scholar
  • 96 Nishiura Y, Kanje M, Lundborg G, Ochiai N, Dahlin L B. Transplantation of cultured Schwann cells to teased tendon grafts and freeze thawed muscle grafts improves nerve regeneration. 8th IFSSH Congress Istanbul, Turkey, June 10 - 14. 2001
    Google Scholar
  • 97 Podhajsky R J, Myers R R. The vascular response to nerve transection: neovascularization in the silicone nerve regeneration chamber.  Brain Res. 1994;  662 88-94
    CrossrefPubMedGoogle Scholar
  • 98 Rich K, Alexander T, Pryor J, Hollowell J. Nerve growth factor enhances regeneration through silicon chambers.  Exp Neurol. 1989;  105 162-170
    CrossrefPubMedGoogle Scholar
  • 99 Rich K M, Luszczynski J R, Osborne P A, Johnson Jr E M. Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury.  J Neurocytol. 1987;  16 261-268
    CrossrefPubMedGoogle Scholar
  • 100 Rodrigues F J, Gomez N, Perego G, Navarro. Highly permeable polyactide-caprolactone nerve guides enhance peripheral nerve regeneration through long gaps.  Biomaterials. 1999;  20 1489-1500
    CrossrefPubMedGoogle Scholar
  • 101 Rodriguez F J, Verdu E, Ceballos D, Navarro X. Nerve guides seeded with autologous Schwann cells improve nerve regeneration.  Exp Neurol. 2000;  161 571-584
    CrossrefPubMedGoogle Scholar
  • 102 Rosen J M, Padilla J A, Nguyen K D, Padilla M A, Sabelman E E, Pham H N. Artificial nerve graft using collagen as an extracellular matrix for nerve repair compared with sutured autograft in a rat model.  Ann Plast Surg. 1990;  25 375-387
    CrossrefPubMedGoogle Scholar
  • 103 Scherman P, Kanje M, Lundborg G, Dahlin L B. Continuous longitudinal sutures - a new and simple approach to repair nerve defects. FESSH Seventh Congress Barcelona, Spain.  J Hand Surg [Br]. 2000;  25 44
    PubMedGoogle Scholar
  • 104 Scherman P, Lundborg G, Kanje M, Dahlin L B. Sutures alone are sufficient to support regeneration across a gap in the continuity of the sciatic nerve in rats.  Scand J Plast Reconstr Surg Hand Surg [Br]. 2000;  34 1-8
    CrossrefPubMedGoogle Scholar
  • 105 Scherman P, Lundborg G, Kanje M, Dahlin L B. Neural regeneration along longitudinal polyglactin sutures across short and extended defects in the rat sciatic nerve.  J Neurosurg. 2001;  95 316-323
    PubMedGoogle Scholar
  • 106 Scherman P, Lundborg G, Kanje M, Dahlin L B. Local effects of triiodothyroninen treated polyglactin sutures enhanced myelination in regeneration across sciatic nerve defects in the rat. VIIth FESSH Congress Amsterdam. 2002
    Google Scholar
  • 107 Seckel B R, Jones D, Hekimian K J, Wang K K, Chakalis D P, Costas P D. Hyaluronic acid through a new injectable nerve guide delivery system enhances peripheral nerve regeneration in the rat.  J Neurosci Res. 1995;  40 318-324
    CrossrefPubMedGoogle Scholar
  • 108 Sondell M, Lundborg G, Kanje M. Regeneration of the rat sciatic nerve into allografts made acellular through chemical extraction.  Brain Res. 1998;  795 44-54
    CrossrefPubMedGoogle Scholar
  • 109 Sondell M, Lundborg G, Kanje M. Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system.  J Neurosci. 1999;  19 5731-5740
    PubMedGoogle Scholar
  • 110 Sterne G D, Brown R A, Green C J, Terenghi G. Neurotrophin-3 delivered locally via fibronectin mats enhances peripheral nerve regeneration.  Eur J Neurosci. 1997;  9 1388-1396
    CrossrefPubMedGoogle Scholar
  • 111 Suzuki Y, Tanihara M, Ohnishi K, Suzuki K, Endo K, Nishimura Y. Cat peripheral nerve regeneration across 50 mm gap repaired with a novel nerve guide composed of freeze-dried alginate gel.  Neurosci Letters. 1999;  259 75-78
    CrossrefPubMedGoogle Scholar
  • 112 Terada N, Bjursten L M, Dohi D, Lundborg G. Bioartificial nerve grafts based on absorbable guiding filament structures - early observations.  Scand J Plast Reconstr Hand Surg. 1997;  31 1-6
    PubMedGoogle Scholar
  • 113 Terada N, Bjursten L M, Papaloizos M, Lundborg G. Resorbable filament structures as a scaffold for matrix formation and axonal growth in bioartificial nerve grafts - long term observations.  Rest Neurol Neurosci. 1997;  11 65-69
    PubMedGoogle Scholar
  • 114 Terada N, Lundborg G, Bjursten L M, Dohi D. The role of macrophages in bioartificial nerve grafts based on resorbable guiding filament structures.  J Med Mat. 1997;  8 391-394
    PubMedGoogle Scholar
  • 115 Tong X, Hirai K I, Shimada H, Mizutani Y, Izumi T, Toda N, Yu P. Sciatic nerve regeneration navigated by laminin-fibronectin double coated biodegradable collagen grafts in rats.  Brain Res. 1994;  663 155-162
    CrossrefPubMedGoogle Scholar
  • 116 Tos P, Battiston B, Geuna S, Giacobini-Robecchi M G, Hill M A, Lanzetta M, Owen E R. Tissue specificity in rat peripheral nerve regeneration through combined skeletal muscle and vein conduit grafts.  Microsurgery. 2000;  20 65-71
    CrossrefPubMedGoogle Scholar
  • 117 Valentini R F, Aebischer P, Winn S R, Galletti P M. Collagen- and laminin-containing gels impede peripheral nerve regeneration through semipermeable nerve guidance channels.  Exp Neurol. 1987;  98 350-356
    CrossrefPubMedGoogle Scholar
  • 118 Valero-Cabre A, Tsironis K, Skouras E, Perego G, Navarro X, Neiss W F. Superior muscle reinnervation after autologous nerve graft or poly-L-lactide-epsilon-caprolactone (PLC) tube implantation in comparison to silicone tube repair.  J Neurosci Res. 2001;  63 214-223
    CrossrefPubMedGoogle Scholar
  • 119 Wang G Y, Hirai K, Shimada H, Taji S, Zhong S Z. Behavior of axons, Schwann cells and perineurial cells in nerve regeneration within transplanted nerve grafts: effects of anti-laminin and anti-fibronectin antisera.  Brain Res. 1992;  583 216-226
    PubMedGoogle Scholar
  • 120 Weber A, Breidenback W C, Brown R E, Jabaley M E, Mass D P. A randomized prospective study of polyglycolic acid conduits for digital nerve reconstruction in humans.  Plast Reconstr Surg. 2000;  106 1036-1045
    CrossrefPubMedGoogle Scholar
  • 121 Whitworth I H, Brown R A, Doré C, Green C J, Terenghi G. Orientated mats of fibronectin as a conduit material for use in peripheral nerve repair.  J Hand Surg [Br]. 1995;  20 429-436
    PubMedGoogle Scholar
  • 122 Whitworth I H, Brown R A, Doré C J, Anand P, Green C J, Terenghi G. Nerve growth factors enhance nerve regeneration through fibronectin grafts.  J Hand Surg [Br]. 1996;  21 514-522
    PubMedGoogle Scholar
  • 123 Whitworth I H, Dore C J, Green C J, Terenghi G. Increased axonal regeneration over long nerve gaps using autologous nerve-muscle sandwich grafts.  Microsurgery. 1995;  16 772-778
    PubMedGoogle Scholar
  • 124 Whitworth I H, Terenghi G, Green C J, Brown R A, Stevens E, Tomlinson D R. Targeted delivery of nerve growth factor via fibronectin conduits assists nerve regeneration in control and diabetic rats.  Eur J Neurosci. 1995;  7 2220-2225
    PubMedGoogle Scholar
  • 125 Wiberg M, Ljungberg C, O'Byrne A, Brown R, Whitworth I, Liss A, Terenghi G. Primary sensory neuron survival following targeted administration of nerve growth factor to an injured nerve.  Scand J Plast Reconstr Hand Surg. 1999;  33 387-392
    PubMedGoogle Scholar
  • 126 Williams L R. Exogenous fibrin matrix precursors stimulate the temporal progress of nerve regeneration within a silicone chamber.  Neurochem Res. 1987;  12 851-860
    CrossrefPubMedGoogle Scholar
  • 127 Wu S, Suzuki Y, Tanihara M, Ohnishi K, Endo K, Nishimura Y. Repair of facial nerve with alginate sponge without suturing: an experimental study in cats.  Scand J Plast Reconstr Surg Hand Surg. 2002;  36 135-140
    CrossrefPubMedGoogle Scholar
  • 128 Yoshii S, Oka M, Ikeda N, Akagi M, Matsusue Y, Nakamura T. Bridging a peripheral nerve defect using collagen filaments.  J Hand Surg [Am]. 2001;  26 52-59
    PubMedGoogle Scholar
  • 129 Yoshii S, Oka M, Shima M, Taniguchi A, Akagi M. 30 mm regeneration of rat sciatic nerve along collagen filaments.  Brain Res. 2002;  949 202-208
    CrossrefPubMedGoogle Scholar
  • 130 Young R C, Wiberg M, Terenghi G. Poly-3-hydroxybutyrate (PHB): a resorbable conduit for long-gap repair in peripheral nerves.  Br J Plast Surg. 2002;  55 235-240
    CrossrefPubMedGoogle Scholar
  • 131 Zamboni W A, Brown R E, Roth A C, Mathur A, Stephenson L L. Functional evaluation of peripheral nerve repair and the effect of hyperbaric oxygen.  J Reconstr Microsurg. 1995;  11 27-29
    Article in Thieme ConnectPubMedGoogle Scholar
  • 132 Zeng L, Worseg A, Albrecht G, Öhlinger W, Redl H, Grisold W, Zatloukal K, Schlag G. Bridging of peripheral nerve defects with exogenous laminin-fibrin matrix in silicone tubes in a rat model.  Rest Neurol Neurosci. 1995;  8 107-111
    PubMedGoogle Scholar
  • 133 Zhao Q, Dahlin L B, Kanje M, Lundborg G. Repair of the transected rat sciatic nerve: Matrix formation within silicone tubes.  Restor Neurol Neurosci. 1993;  5 197-204
    PubMedGoogle Scholar

Prof. Dr. med. Göran Lundborg

Department of Hand Surgery
Malmö University Hospital

20502 Malmö

Sweden

Email: goran.lundborg@hand.mas.lu.se

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