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Planta Med 2004; 70(3): 269-272
DOI: 10.1055/s-2004-818922
Letter
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic ent-Kaurane Diterpenoids from Isodon rubescens var. rubescens

Quan-Bin Han1 , Wei Xiang1 , Rong-Tao Li1 , Ma-Lin Li2 , Si-Wei Li2 , Han-Dong Sun1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • 2Yunnan Pharmacological Laboratory of Natural Products, Kunming Medical College, Kunming, P. R. China
Further Information

Publication History

Received: July 28, 2003

Accepted: November 15, 2003

Publication Date:
23 March 2004 (online)

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Abstract

Five new ent-kauranoids, xindongnins C - G (1 - 5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6 - 10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

References

  • 1 Sun H D, Lin Z W, Qin C Q, Cao J H, Zhao Q Z. Studies on the chemical constituents of antitumor plant Rabdosia rubescens (Hemsl.) Hara.  Acta Botanica Yunnanica. 1981;  3 95-100
    PubMedSearch in Google Scholar
  • 2 Han Q B, Mei S X, Jiang B, Zhao A H, Sun H D. New ent-kaurane diterpenoids from Isodon rubescens .  Chinese Journal of Organic Chemistry. 2003;  23 270-3
    PubMedSearch in Google Scholar
  • 3 Han Q B, Li S H, Peng L Y, Sun H D. Ent-kaurane diterpenoids from Isodon rubescens var. lushiensis .  Heterocycles. 2003;  60 933-8
    PubMedSearch in Google Scholar
  • 4 Han Q B, Jiang B, Zhang J X, Niu X M, Sun H D. Two novel ent-kaurene diterpenoids from Isodon rubescens .  Helvetica Chimica Acta. 2003;  86 773-7
    CrossrefPubMedSearch in Google Scholar
  • 5 Han Q B, Li M L, Li S H, Mou Y K, Lin Z W, Sun H D. Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis .  Chemical and Pharmaceutical Bulleltin. 2003;  51 790-3
    CrossrefPubMedSearch in Google Scholar
  • 6 Han Q B, Zhao Q S, Li S H, Peng L Y, Sun H D. Ent-kaurane diterpenoids from Isodon rubescens collected in Guizhou Province.  Acta Chimica Sinica. 2003;  61 1077-82
    PubMedSearch in Google Scholar
  • 7 Sun H D, Lin Z W, Fu J, Zheng X R, Gao Z Y. Studies on the structures of xindongnins A and B.  Acta Chimica Sinica. 1985;  2 127-34
    PubMedSearch in Google Scholar
  • 8 Wang J L, Zhang L J, Miao F M, Sun H D, Gong Y H. Structures of xindongnin B.  Acta Cryst. 1992;  48 1853-5
    PubMedSearch in Google Scholar
  • 9 Zhao Q Z, Wang G H, Zheng Z A, Xue H Z, Zhang Y B, Sun H D, Shen X Y, Lin Z W. The diterpenoids from Rabdosia dawoensis .  Acta Botanica Yunnanica. 1991;  13 205-8
    PubMedSearch in Google Scholar
  • 10 Zhao Q S, Lin Z W, Jiang B, Wang J, Sun H D. Glabcensins V-Y, four ent-kaurane diterpenoids from Isodon angustifolius var. glabrecens .  Phytochemistry. 1999;  50 123-6
    CrossrefPubMedSearch in Google Scholar
  • 11 Zhao Q S, Jiang B, Lin Z W, Sun H D. Chemical constituents of Isodon melissoides .  Journal of Asian Natural Products Research. 1999;  1 277-84
    PubMedSearch in Google Scholar
  • 12 Niu X M, Li S H, Li M L, Zhao Q S, Mei S X, Na Z, Wang S J, Lin ZW and Sun H D. Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora .  Planta Medica. 2002;  68 528-33
    Thieme ConnectPubMedSearch in Google Scholar
  • 13 Node M. Research and development of new anticancer agent from Isodon japonica and I. trichocarpa .  Suzuken Memorial Foundation. 1984;  3 112-8
    PubMedSearch in Google Scholar

Prof. Dr. Han-Dong Sun

State Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

Chinese Academy of Sciences

Heilongtan

Kunming 650204

People’s Republic of China

Fax: +86 871 5216343

Email: hdsun@mail.kib.ac.cn