New Halimane Diterpenoids from Croton oblongifolius

Sophon Roengsumran; Surachai Pornpakakul; Nongnuj Muangsin; Polkit Sangvanich; Thumnoon Nhujak; Pravit Singtothong; Narongsak Chaichit; Songchan Puthong; Amorn Petsom

doi:10.1055/s-2004-815466

Planta Med 2004; 70(1): 87-89
DOI: 10.1055/s-2004-815466

Letter

New Halimane Diterpenoids from Croton oblongifolius

Sophon Roengsumran¹ , Surachai Pornpakakul¹ , Nongnuj Muangsin¹ , Polkit Sangvanich¹ , Thumnoon Nhujak¹ , Pravit Singtothong¹ , Narongsak Chaichit² , Songchan Puthong³ , Amorn Petsom³

¹Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
²Department of Physics, Faculty of Science and Technology, Thammasart University, Rangsit, Pathum Thani, Thailand
³Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok, Thailand

The authors express their gratitude to the Rachadapiseksompoj Endowment and Graduate School, Chulalongkorn University for financial support. We also thank the National Research Council of Thailand for partial financial support.

Abstract

Three new halimane-type diterpenoids, crotohalimaneic acid (1), crotohalimoneic acid (2) and 12-benzoyloxycrotohalimaneic acid (3), were isolated from the stem bark of Croton oblongifolius Roxb. Their structures were established on the basis of spectroscopic and X-ray analysis. Compounds 1 and 2 showed non-specific strong cytotoxicity against a panel of human tumor cell lines; whereas 3 was inactive.

Full Text

References

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Dr. Sophon Roengsumran

Department of Chemistry

Faculty of Science

Chulalongkorn University

Bangkok 10330

Thailand

Fax: +66-2-218-7598

Email: amorn.p@chula.ac.th