Radiologie up2date 2004; 4(2): 107-122
DOI: 10.1055/s-2004-814547
Neuroradiologie
© Georg Thieme Verlag Stuttgart · New York

Formale MRT-Kriterien in der Diagnose der Multiplen Sklerose

Formal MRI Criteria for the Diagnosis of Multiple SclerosisInga  Harting1 , Uta  Meyding-Lamadé2 , Stefan  Hähnel1
  • 1Abteilung Neuroradiologie, Neurologische Klinik, Universitätsklinikum Heidelberg
  • 2Neurologische Klinik, Universitätsklinikum Heidelberg
Further Information

Publication History

Publication Date:
19 July 2004 (online)

Zusammenfassung

Die multiple Sklerose (MS) ist die häufigste entzündliche, demyelinisierende Erkrankung des ZNS, die mit multiplen, disseminierten Demyelinisierungsherden, sog. Plaques, in der weißen Substanz einhergeht.

Die MRT weist mit hoher Sensitivität Veränderungen der weißen Substanz nach. Indem die MRT bereits bei einer klinisch isolierten, MS-verdächtigen Erstsymptomatik die räumliche und zeitliche Disseminierung der Erkrankung belegt, trägt die Methode dazu bei, die Erkrankungswahrscheinlichkeit abzuschätzen. Da die MRT zwar hoch sensitiv, aber nicht spezifisch ist, ist die Anwendung formaler MRT-Kriterien für die Diagnose der MS sehr wichtig. Dieser Artikel beschreibt die charakteristischen MRT-Veränderungen der MS und die sog. McDonald-Kriterien einer MRT-gestützten Diagnose der MS.

Abstract

Multiple sclerosis (MS) is the most common demyelinating inflammatory disease of the central nervous system, presenting with multifocal, disseminated white matter lesions called plaques.

Magnetic resonance imaging (MRI) is very sensitive in detecting white matter abnormalities. By demonstrating the spatial and temporal dissemination in patients presenting with isolated clinical findings suggestive of MS, MRI contributes to estimating the likelihood of the disease. Since MRI is highly sensitive but not specific, it is important to apply formal MRI criteria. This article describes the characteristic MRI changes of MS and the so-called McDonald criteria for an MRI-supported diagnosis of MS.

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Dr. med. Inga Harting

Abteilung Neuroradiologie
Neurologische Klinik
Universitätsklinikum Heidelberg

Im Neuenheimer Feld 400
69120 Heidelberg

Phone: 0622/567564

Fax: 06221/564673

Email: inga.harting@med.uni-heidelberg.de

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