Horm Metab Res 2004; 36(3): 178-182
DOI: 10.1055/s-2004-814343
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Weight Gain and Cardiovascular Risk Factors During Smoking Cessation with Bupropion or Nicotine

J.  I.  Botella-Carretero1 , H.  F.  Escobar-Morreale1 , I.  Martín2 , A.  M.  Valero3 , F.  Alvarez1 , G.  García1 , C.  Varela1 , M.  Cantarero2
  • 1Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain
  • 2Unit of Endocrinology, Nutrition and Dietetics, Gabinete Médico Velázquez, Madrid, Spain
  • 3Unit of Pulmonology and Allergy, Gabinete Médico Velázquez, Madrid, Spain
Weitere Informationen

Publikationsverlauf

Received 15 May 2003

Accepted after revision 13 October 2003

Publikationsdatum:
01. April 2004 (online)

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Abstract

Weight gain is frequent after smoking cessation, and may limit patient’s will to quit and long-term success. Nicotine and bupropion are effective drugs for smoking withdrawal. However, their influence on weight gain, insulin resistance and other cardiovascular risk factors, as well as possible differences in obese and lean subjects, have not been fully evaluated. We randomised 25 lean and 25 obese smokers to receive either bupropion or nicotine patches. Clinical evaluation and lipid profile were performed at baseline and after treatment. Insulin resistance was also assessed at the end. Weight, BMI, waist-to-hip ratio, and diastolic blood pressure increased (p < 0.005), whereas lipid profile improved (p < 0.001) after smoking cessation independently of obesity at baseline or drug used. Obese patients had higher insulin resistance at the end (p < 0.05) regardless of drug used. Weight gain was inversely related to age (β= - 0.125, R = 0.38, p = 0.046), and insulin resistance was related to obesity at baseline (β = 0.85, R = 0.46, p = 0.02). In conclusion, weight gain after smoking cessation is not dependent on obesity or drug taken. A beneficial lipid profile is achieved after quitting smoking with either bupropion or nicotine patch in both obese and lean subjects.

References

J. I. Botella-Carretero

Department of Endocrinology · Hospital Ramón y Cajal

Carretera de Colmenar 9,100 · Madrid 28034 · Spain

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