Aktueller Stand der Diagnostik gastrointestinaler Stromatumoren aus der Sicht der Pathologie

GIST - Cajal-Zellen - Kit - PDGF-Rezeptor

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• 2 Miettinen M, Monihan J M, Sarlomo-Rikala M. et al . Gastrointestinal stromal tumors/smooth muscle tumors (GIST) primary in the omentum and mesentery: clinicopathological and immunohistochemical study of 26 cases.  Am J Surg Pathol. 1999;  23 1109-1118
• 3 Fletcher C D, Berman J, Corless C L. et al . Diagnosis of gastrointestinal stromal tumors: A consensus approach.  Hum Pathol. 2002;  33 459-465
• 4 Miettinen M, El-Rifai W, Sobin L H. et al . Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review.  Hum Pathol. 2002;  33 478-483
• 5 Hirota S, Isozaki K, Moriyama Y. et al . Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.  Science. 1998;  279 577-580
• 6 Wardelmann E, Losen I, Hans V. et al . Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors.  Int J Cancer. 2003;  106 887-895
• 7 Heinrich M C, Corless C L, Duensing A. et al . PDGFRA activating mutations in gastrointestinal stromal tumors.  Science. 2003;  299 708-710
• 8 Hirota S, Ohashi A, Nishida T. et al . Gain-of-function mutations in platelet-derived growth factor receptor a gene in gastrointestinal stromal tumors.  Gastroenterology. 2003;  125 660-667
• 9 Wardelmann E, Hrychyk A, Merkelbach-Bruse S. et al . Association of platelet-derived growth factor receptor alpha mutations with gastric primary site and epithelioid or mixed cell morphology in gastrointestinal stromal tumors.  J Mol Diagn. 2004 (in press); 
• 10 Wardelmann E, Neidt I, Bierhoff E. et al . c-kit mutations in gastrointestinal stromal tumors occur preferentially in the spindle rather than in the epithelioid cell variant.  Mod Pathol. 2002;  15 125-136
• 11 Heinrich M C, Corless C L, Demetri G D. et al . Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumors.  J Clin Oncol. 2003;  21 4342-4349
• 12 Debiec-Rychter M, Dumez H, Judson I. et al . Use of c-kit/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group.  Eur J Cancer. 2004;  40 689-695