Abstract
Common molecular changes in cancer cells are high carbon flux through the glycolytic
pathway and overexpression of fatty acid synthase, a key lipogenic enzyme. Since glycerol
3-phosphate dehydrogenase creates a link between carbohydrates and the lipid metabolism,
we have investigated the activity of glycerol 3-phosphate dehydrogenase and various
lipogenic enzymes in human bladder cancer.
The data presented in this paper indicate that glycerol 3-phosphate dehydrogenase
activity in human bladder cancer is significantly higher compared to adjacent non-neoplastic
tissue, serving as normal control bladder tissue. Increased glycerol 3-phosphate dehydrogenase
activity is accompanied by increased enzyme activity, either directly (fatty acid
synthase) or indirectly (through ATP-citrate lyase, glucose 6-phosphate dehydrogenase,
6-phosphogluconate dehydrogenase and citrate synthase) involved in fatty acid synthesis.
Coordinated upregulation of glycerol 3-phosphate dehydrogenase and lipogenic enzymes
activities in human bladder cancer suggests that glycerol 3-phosphate dehydrogenase
supplies glycerol 3-phosphate for lipid biosynthesis.
Key words
Glycerol 3-phosphate dehydrogenase - Lipogenic enzymes - Bladder cancer
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J. Swierczynski, M. D., Ph. D.
Department of Biochemistry · Medical University of Gdansk
ul. Debinki 1 · 80-211 Gdansk · Poland
Fax: +48 (58) 349 14 65
eMail: juls@amg.gda.pl
