Abstract
A new cyclopeptide, grifficyclocin A (1 ), and a new aporphine alkaloid, griffinin (2 ) were isolated together with two known styryllactones from the stems of Goniothalamus griffithii . Their structures were identified spectroscopically and chemically. Among them, the
griffinin (2) was isolated as the enol form in two tautomers, and the two known styryllactones,
goniothalamin (3 ) and 8-O -acetylgoniotriol (4 ), showed selective in vitro antitumor activities.
Key words
Goniothalamus griffithii
- Annonaceae - cyclopeptide - grifficyclocin A - griffinin - styryllactone
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Dr. Qing Mu
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Pharmacy School
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