Planta Med 2003; 69(8): 767-770
DOI: 10.1055/s-2003-42794
Letter
© Georg Thieme Verlag Stuttgart · New York

Identification of an Anti-Inflammatory Principle from the Stem Bark of Millettia versicolor

Maurice Tagatsing Fotsing1 , Emmanuel Yankep1 , Dieudonné Njamen2 , Z. Tanee Fomum1 , Barthelemy Nyasse1 , B. Bodo3 , M. Carmen Recio4 , Rosa M. Giner4 , José-Luis Ríos4
  • 1Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon
  • 2Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon
  • 3Laboratoire de Chimie U.RA. 401, CNRS, Museum National d'Histoire Naturelle, Paris, France
  • 4Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain
Part 12 of the series Milletia of Cameroon
Further Information

Publication History

Received: December 16, 2002

Accepted: April 26, 2003

Publication Date:
06 October 2003 (online)

Abstract

The dichloromethane-soluble fraction of the methanol extract of the stem bark of Millettia versicolor Welw. (Leguminosae) has been shown to possess anti-inflammatory activity. The chromatographic fractionation and subsequent analysis of the spectroscopic data of this extract led to the isolation and identification of 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone (1) along with two known quinones. Pharmacological data demonstrate that compound 1 has relevant anti-inflammatory properties whereas the other two isolated compounds do not.

References

  • 1 Irvine F R. Woody Plants of Ghana. London; Oxford University Press 1961: pp. 393-6
  • 2 Dewick P. Isoflavonoids.  In: The Flavonoids: Advances in Research since 1986. Harborne JB, editor New York; Chapman and Hall 1994: pp. 117-238
  • 3 Bisby F A, Buckingham J, Harbone J B. Phytochemical Dictionary of Leguminosae. London; Chapman and Hall 1994
  • 4 Ngamga D, Fanso Free S NY, Fomum Z T, Martin M T, Bodo B. A new guanidine alkaloid from Millettia laurentii .  J Nat Prod. 1994;  57 1022-4, and references cited therein
  • 5 Kamnaing P, Fanso Free S NY, Fomum Z T, Martin M T, Bodo B. Millettonine, a guanidine alkaloid from Millettia laureentii .  Phytochemistry. 1994;  36 1561-2
  • 6 Wagner H, Kreher B, Lotter H, Hamburger M O, Cordell G A. Structure determination of new isomeric naphtho[2,3-b]furan-4,9-diones from Tabebuia avellanedea by the selective-INEPT technique.  Helv Chim Acta. 1989;  72 659-67
  • 7 Zani C L, de Oliveira A B, de Oliveira G G. Furanonaphthoquinones from Tabebuia ochracea .  Phytochemistry. 1991;  30 2379-81
  • 8 Thomson R H. Naturally occurring Quinones III, Recent Advances. London; Chapman and Hall 1987: p. 147
  • 9 Giner R M, Villalba M L, Recio M C, Mánez S, Cerdá-Nicolás M, Ríos J L. Anti-inflammatory glycoterpenoids from Scrophularia auriculata .  Eur J Pharmacol. 2000;  389 243-52
  • 10 Giner-Larza E M, Mánez S, Recio M C, Giner R M, Prieto J M, Cerdá-Nicolás M, Ríos J L. Anti-inflammatory triterpenes from Pistacia terebinthus galls.  Planta Med. 2002;  68 311-5
  • 11 Mosmann T. Rapid colorimetric assay for cellular growth and survival: applications to proliferation and cytotoxicity assays.  J Immunol Methods. 1983;  65 55-63
  • 12 Safayhi H, Sailer S, Havens M. Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-β-boswellic acid.  Mol Pharmacol. 1995;  47 1212-6
  • 13 Prieto J M, Giner R M, Recio M C, Schinella G, Manez S, Rios J L. Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum .  Planta Med. 2002;  68 359-60

J. L. Ríos

Departament de Farmacologia

Facultat de Farmàcia

Universitat de València

Vicent Andrés Estellés s/n

46100 Burjassot (Valencia)

Spain

Phone: /Fax: +34-963-544-973

Email: riosjl@uv.es

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