Germacrane Sesquiterpene Esters from Salvia roborowskii

Abstract

From the whole plant of Salvia roborowskii, four new germacrane sesquiterpene esters, 3β,6β,8α-triacetoxy-4β,5α-epoxy-1-oxogermacr-10(14)-ene, 3β,6β,8α-triacetoxy-4β,5α-epoxygermacr-1 (10)E-ene, 3β,6β,8α-triacetoxy-4β,5α:1α,10β-diepoxygermacrane and 6β-acetoxyglechomafuran were isolated, and their structures were elucidated by spectroscopic methods including 2D NMR techniques (¹H-¹H COSY and ¹H-¹H NOESY for 1).

References

• 1 Name Reference of Chinese herbal medicine of the whole country. People’s Health Press Beijing; 1996: p. 938
• 2 Wang S F, Li S, Li Z G, Li Y. Triterpenoids and other compounds from Salvia roborowskii Maxim.  Pharmazie. 2001;  56 420-2
• 3 Miski M, Moubasher H A, Mabry T J. Sesquiterpene aryl esters from Ferulago antiochia .  Phytochemistry. 1990;  29 881-6
• 4 Hayashi K I, Asano K I, Tanaka M, Takaoka D, Nozaki H. Biotransformation of shiromodiol diacetate, myli-4(15)-en-9-one and myliol by Aspergillus niger .  Phytochemistry. 1998;  48 461-6
• 5 Shi Y P, Guo W, Jia Z J. Germacranolides from Carpesium lipskyi .  Planta Med. 1999;  65 94-6
• 6 Barrero A F, Herrador M M, Quilez J F, Manzaneda R A, Portal D olores, Gavin J A, Gravalos D G, Simmonds M SJ, Blaney W M. Bioactive sesquiterpenes from Santolina rosmarinifolia subsp. canescens. A conformational analysis of the germacrane ring.  Phytochemistry. 1999;  51 529-41
• 7 Ulubelen A, ÖKsüz S. Relative configuration of glechomafuran isolated from the fruits of Smyrnium olusatrum .  J Nat Prod. 1983;  46 490-2
• 8 Ulubelen A, Gören N, Bohlmann F, Jakupovic J, Grenz M, Tanker N. Sesquiterpene lactones from Smyrnium cordifolium .  Phytochemistry. 1985 ;  24 1305-8