Variation of Podophyllotoxin in Leaves of Eastern Red Cedar (Juniperus virginiana)

Kent E. Cushman; Muhammad Maqbool; Patrick D. Gerard; Ebru Bedir; Hemant Lata; Rita M. Moraes

doi:10.1055/s-2003-39707

Planta Medica, Inhaltsverzeichnis

Planta Med 2003; 69(5): 477-478
DOI: 10.1055/s-2003-39707

Letter

Variation of Podophyllotoxin in Leaves of Eastern Red Cedar (Juniperus virginiana)

Kent E. Cushman¹ , Muhammad Maqbool¹ , Patrick D. Gerard² , Ebru Bedir³ , Hemant Lata³ , Rita M. Moraes³

¹North Mississippi Research & Extension Center, Mississippi State University, Verona, Mississippi, USA
²Experimental Statistical Unit, Mississippi State University, Mississippi State, Mississippi, USA
³National Center for Natural Products Research, Thad Cochran Research Center, School of Pharmacy, University of Mississippi, University, Mississippi, USA

Abstract

Leaves of Eastern red cedar (Juniperus virginiana L. Cupressaceae) have been reported to contain podophyllotoxin, a pharmaceutical compound used to manufacture drugs for treatment of cancer, rheumatoid arthritis, genital warts, psoriasis, and multiple sclerosis. Podophyllotoxin content of leaves of immature, mature male, and mature female plants (∼1.45 mg·g^-1) was significantly higher than that of leaves of juvenile plants (0.60 mg·g^-1). Sampling date also affected podophyllotoxin content. Leaves harvested in January and April exhibited higher podophyllotoxin contents (1.56 and 1.45 mg·g^-1, respectively) than leaves harvested in February and June (1.06 and 1.08 mg·g^-1, respectively). There was no obvious pattern or trend in the data due to sampling date. There was no significant interaction between plant type and sampling date. These results indicate that foliage of mature Eastern red cedar, a waste product of the lumber industry, could be a low-yielding, but relatively stable, source of podophyllotoxin.

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Referenzen

References

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Dr. Kent E. Cushman

North Mississippi Research & Extension Center

P.O. Box 1690

Verona

MS 38879

USA

eMail: kcushman@ra.msstate.edu

Fax: +1-662-566-2257