Abstract
A new ursane-type triterpenoid, 3β,11α,21α-trihydroxyurs-12-ene, named salvistamineol
(1), has been isolated from the methanol extract of Salvia staminea. In addition to 1, the methanol extract yielded four known compounds and the acetone extract yielded
twelve known compounds consisting of two sesquiterpenes, six diterpenoids, a triterpenoid,
two steroids and one flavone. DNA damaging properties of the extracts and some isolated
diterpenes were investigated against three yeasts and only taxodione gave a positive
response and also showed the highest cytotoxic activity against a panel of cell lines
among the investigated compounds in this study.
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Prof. Dr. Gülaçti Topcu
Istanbul University
Faculty of Pharmacy
34452 Beyazit-Istanbul
Turkey
Email: gulacti_topcu@hotmail.com
Fax: +90-212-519 08 12
