Abstract
Labda-7,12(E),14-triene-17-oic acid, previously isolated from Croton oblongifolius, and its derivatives were investigated for cytotoxicity against five human tumor cell lines. Six of these compounds, labda-7,12(E),14-triene-17-al, 17-hydroxylabda-7,12(E),14-triene, 17-acetoxylabda-7,12(E),14-triene, 15-hydroxylabda-7,13(E)-diene-17,12-olide, labda-7,13(E)-diene-17,12-olide, and 12,17-dihydroxylabda-7,13(E)-diene showed non-specific, moderate, cytotoxicity against all cell lines, whereas the other compounds were inactive.
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Dr. Sophon Roengsumran
Department of Chemistry
Faculty of Science
Chulalongkorn University
Phayathai Rd.
Pathumwan
Bangkok 10330
Thailand
Fax: +66-2-253-0321
Email: amorn.p@chula.ac.th
