Download PDF
Skull Base 2003; 13(1): 013-020
DOI: 10.1055/s-2003-37549
ORIGINAL ARTICLE

Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Clinical and Histologic Parameters Correlated with Facial Nerve Function After Vestibular Schwannoma Surgery

Vincent Couloigner1,2 , Elena Gervaz3 , Michel Kalamarides4 , Evelyne Ferrary2 , Alain Rey4 , Olivier Sterkers1,2 , Dominique Hénin5
  • 1Department of Oto-Rhino-Laryngology, Hôpital Beaujon, AP-HP, Clichy, France
  • 2INSERM EMI-U 0112, Faculté Xavier Bichat, Paris, France
  • 3Department of Pathology, Hôpital Beaujon, AP-HP, Clichy, France
  • 4Department of Neurosurgery, Hôpital Beaujon, AP-HP, Clichy, France
  • 5Department of Pathology, Hôpital Bichat, AP-HP, Paris, France
Further Information

Publication History

Publication Date:
10 March 2003 (online)

    Permissions and Reprints

ABSTRACT

This study was conducted to identify clinical and histologic factors that would influence, independently of tumor staging, postoperative facial function after removal of a vestibular schwannoma. A prospective study was performed on 35 consecutive patients with vestibular schwannomas who underwent the translabyrinthine approach. Facial function was assessed before and 1 year after surgery. The factors that influenced the postoperative outcome of the facial function independently of tumor staging were the absence or the desynchronization of homolateral auditory brainstem responses and tumor edema. Other factors (audiovestibular signs of brainstem compression, tumor inflammation, positive p53 protein immunostaining) were predictive of postoperative facial function but also correlated with tumor staging. Besides the well-known prognostic value of tumor staging for postoperative facial outcome, clinical (auditory brainstem responses) and histologic (tumor edema) factors correlated with postoperative facial function.

KEYWORDS

Acoustic neuroma - facial palsy - p53 protein - Ki-67 - flow cytometry

REFERENCES

  • 1 Driscoll C LW. Vestibular schwannoma (acoustic neuroma). In: Jackler RK, Driscoll CLW, eds. Tumors of the Ear and Temporal Bone Philadelphia, PA: Lippincott Williams Wilkins 2000 0: 172-218
    Google Scholar
  • 2 House W F. Case summaries.  Arch Otolaryngol . 1968;  88 586-591
    CrossrefPubMedGoogle Scholar
  • 3 Delgado T E, Bucheit W A, Rosenholtz H R, Chrissian S. Intraoperative monitoring of facial muscle evoked responses obtained by intracranial stimulation of the facial nerve: a more accurate technique for facial nerve dissection.  Neurosurgery . 1979;  4 418-421
    CrossrefPubMedGoogle Scholar
  • 4 House J W, Brackmann D E. Facial nerve grading system.  Otolaryngol Head Neck Surg . 1985;  93 146-147
    Google Scholar
  • 5 Sterkers J M, Morrison G AJ, Sterkers O, Badr el Dine M K M. Preservation of facial, cochlear, and other nerve functions in acoustic neuroma treatment.  Otolaryngol Head Neck Surg . 1994;  110 146-155
    PubMedGoogle Scholar
  • 6 Samii M, Matthies C. Management of 1000 vestibular schwannomas (acoustic neuromas): the facial nerve-preservation and restitution of function.  Neurosurgery . 1997;  40 684-695
    CrossrefPubMedGoogle Scholar
  • 7 Sampath P, Holliday M J, Brem H, Niparko J K, Long D M. Facial nerve injury in acoustic neuroma (vestibular schwannoma) surgery: etiology and prevention.  J Neurosurg . 1997;  87 60-66
    CrossrefPubMedGoogle Scholar
  • 8 Wiegand D A, Ojemann R G, Fickel V. Surgical treatment of acoustic neuroma (vestibular schwannoma) in the United States: report from the Acoustic Neuroma Registry.  Laryngoscope . 1996;  106 58-66
    PubMedGoogle Scholar
  • 9 Kartush J M, Lundy L B. Facial nerve outcome in acoustic neuroma surgery.  Otolaryngol Clin North Am . 1992;  3 623-647
    PubMedGoogle Scholar
  • 10 Mason D Y, Sammons R E. The labeled antigen method of immunoenzymatic staining.  J Histochem Cytochem . 1979;  27 832-840
    PubMedGoogle Scholar
  • 11 Graham R C, Karnovsky M J. The early stages of absorption of horseradish peroxydase in proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.  J Histochem Cytochem . 1966;  14 291-302
    PubMedGoogle Scholar
  • 12 Fléjou J F, Muzeau F, Potet F, Lepelletier F, Fekete F, Hénin D. Overexpression of the p53 tumor suppressor gene product in oesophageal and gastric carcinomas.  Pathol Res Pract . 1994;  190 1141-1148
    PubMedGoogle Scholar
  • 13 Dean P N, Jett J H. Mathematical analysis of DNA distributions derived from flow microfluorometry.  J Cell Biol . 1974;  60 523-527
    CrossrefPubMedGoogle Scholar
  • 14 Fenton J E, Chin R Y, Shirazi A, Fagan P A. Prediction of postoperative facial nerve function in acoustic neuroma surgery.  Clin Otolaryngol . 1999;  24 483-486
    CrossrefPubMedGoogle Scholar
  • 15 Deguine O, Maillard A, Bonafe A, el Adouli H, Tremoulet M, Fraysse B. Pre-operative and per-operative factors conditioning long-term facial nerve function in vestibular schwannoma surgery through translabyrinthine approach.  J Laryngol Otol . 1998;  112 441-445
    PubMedGoogle Scholar
  • 16 Gomez-Brouchet A, Delisle M B, Cognard C. Vestibular schwannomas: correlations between magnetic resonance imaging and histopathologic appearance.  Otol Neurotol . 2001;  22 79-86
    CrossrefPubMedGoogle Scholar
  • 17 Monoh K, Ishikawa K, Yasui N, Mineura K, Andoh H, Togawa K. p53 tumor suppressor gene in acoustic neuromas.  Acta Otolaryngol (Suppl) . 1998;  537 11-15
    PubMedGoogle Scholar
  • 18 Grey P L, Moffat D A, Palmer C R, Hardy D G, Baguley D M. Factors which influence the facial nerve outcome in vestibular schwannoma surgery.  Clin Otolaryngol . 1996;  21 409-413
    CrossrefPubMedGoogle Scholar
  • 19 Antoni N RE. Uber Rückenmarkstumoren und Neurofibrome.  München: Bergmann 1920: 311-318
    Google Scholar
  • 20 Martin C, Chelik L, Prades J M, Duthel R, Dumollard J M. Acoustic neuromas: evolutive factors. In: Sterkers JM, Charachon R, Sterkers O, eds. Acoustic Neuroma and Skull Base Surgery Amsterdam: Kugler Publications 1996: 37-45
    Google Scholar
  • 21 Labit-Bouvier C, Crebassa B, Bouvier C, Andrac-Meyer L, Magnan J. Clinicopathologic growth factors in vestibular schwannomas: a morphological and immunohistochemical study of 69 tumours.  Acta Otolaryngol (Stockh) . 2000;  120 950-954
    Google Scholar
  • 22 Charabi S, Simonsen K, Charabi B. Nerve growth factor receptor expression in heterotransplanted vestibular schwannoma in athymic nude mice.  Acta Otolaryngol (Stockh) . 1996;  116 59-63
    PubMedGoogle Scholar
  • 23 Grey P L, Moffat D A, Palmer C R, Hardy D G, Baguley D M. Factors which influence the facial nerve outcome in vestibular schwannoma surgery.  Clin Otolaryngol . 1996;  21 409-413
    CrossrefPubMedGoogle Scholar
      >