Abstract
6-Shogaol, a constituent of Zingiber officinale, improved carbachol-induced accelerated small intestinal transit in vivo, as well as improving longitudinal muscle contraction induced by low-frequency electrical
stimulation of the isolated guinea pig small intestine in vitro. In addition, 6-shogaol ameliorated BaCl2-induced hyperperistalsis of the small intestine in vivo.
References
- 1
Horie Y, Kato K, Hamano K.
An overview of our surgery-oriented Kampo. J.
Tokyo Women’s Medical College.
1995;
65
43-51
- 2
Furukawa Y, Shiga Y, Hanyu N, Hashimoto Y, Mukai H, Nishikawa K, Aoki T.
Effect of Chinese herbal medicine on gastrointestinal motility and bowel obstruction.
Japan. J. Gastroenterol.
Surg..
1995;
28
956-60
- 3
Satoh K, Kase Y, Hayakawa T, Murata P, Ishige A, Sasaki H.
Dai-kenchu-to enhances accelerated small intestinal movement.
Biological Pharmaceutical Bulletin.
2001;
24
1122-6
- 4
Taniyama K, Sano I, Nakayama S, Matsuyama S, Takeda K, Yoshihara C, Tanaka C.
Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid
receptors.
Gastroenterology.
1991;
101
1579-87
- 5
Famaey J P, Fontaine J, Reuse J.
The effects of non-steroidal anti-inflammatory drugs on cholinergic and histamine-induced
contractions of guinea-pig isolated ileum.
Br J Pharmacol..
1977;
60
165-71
- 6
Shoji N, Iwasa A, Takemoto T, Ishida Y, Ohizumi Y.
Cardiotonic principle of Ginger.
J Pharmaceutical Sciences.
1982;
71
1174-5
- 7
Hatanaka M, Himeda Y, Imashiro R, Tanaka Y, Ueda I.
Allylidenetriphenylphosphorane as a bifunctional reagent.
J Organic Chemistry.
1994;
59
111-9
- 8
Yokochi E, Kohno S, Ohata K.
Pharmacological studies on the clathrate compound of mobenzoxamine with β-cyclodextrin
(1) Effects on the digestive system.
Folia pharmacol japon.
1988;
92
297-310
Ph. D. Kazunori Hashimoto
Kampo & Pharmacognosy Laboratory
Tsumura & Co.
3586 Yoshiwara
Ami-machi
Inashiki-gun
Ibaraki 300-1192
Japan
Fax: +81-298-89-3825
Email: hashimoto_kazunori@ mail.tsumura.co.jp